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中华关节外科杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 379 -384. doi: 10.3877/cma.j.issn.1674-134X.2018.03.014

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综述

髌下脂肪垫来源间充质干细胞软骨分化的研究进展
陈墅1, 周义钦1, 周嵘1, 钱齐荣1,()   
  1. 1. 200003 上海,海军军医大学附属长征医院关节外科
  • 收稿日期:2017-06-02 出版日期:2018-06-01
  • 通信作者: 钱齐荣

Research progress of infrapatellar fat pad derived adipose stem cells differentiating into cartilage

Shu Chen1, Yiqin Zhou1, Rong Zhou1, Qirong Qian1,()   

  1. 1. Department of the joint surgery, Shanghai Changzheng Hospital, Shanghai 200003, China
  • Received:2017-06-02 Published:2018-06-01
  • Corresponding author: Qirong Qian
  • About author:
    Corresponding author: Qian Qirong, Email:
引用本文:

陈墅, 周义钦, 周嵘, 钱齐荣. 髌下脂肪垫来源间充质干细胞软骨分化的研究进展[J/OL]. 中华关节外科杂志(电子版), 2018, 12(03): 379-384.

Shu Chen, Yiqin Zhou, Rong Zhou, Qirong Qian. Research progress of infrapatellar fat pad derived adipose stem cells differentiating into cartilage[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(03): 379-384.

间充质干细胞(MSCs)为重点的组织工程学研究已成为软骨损伤修复与再生的研究热点,髌下脂肪垫(IPFP)是脂肪间充质干细胞(ASCs)的新型优良组织来源,其取材方便,供区损伤小。且IPFP-ASCs体外增殖快,成软骨分化能力较强。低氧,转化生长因子β1、β3,骨形态发生蛋白7等可以促进其分化。体内试验表明其可以有效改善软骨损伤患者症状,提高关节功能。虽然目前仍存在生物学和技术上的困难需克服,但IPFP-ASCs有望成为修复包括骨关节炎在内的关节软骨损伤的良好策略。

Tissue engineering approaches for promoting the repair of cartilage lesions have focused on cell-based therapies involving mesenchymal stem cells(MSCs). Infrapatellar fat pad (IPFP) is an attractive cell resource of the adipose mesenchymal stem cells(ASCs), which can be collected and harvested by a convenient and minimally invasive procedure. The proliferation of IPFP-ASCs in vitro is fast and the ability to differentiate into cartilage is relatively strong. Hypoxia, TGF-β1, TGF-β3, BMP-7 have been proved to be able to enhance the chondrogenesis of infrapatellar fat pad derived adipose stem cells. In vivo studies indicate that application of IPFP-ASCs can effectively improve symptoms of cartilage injury and joint function. Although there are biological and technical difficulties to be overcome, the implantation of IPFP-ASCs are expected to become a good strategy to repair articular cartilage injury, including osteoarthritis.

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