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中华关节外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 694 -700. doi: 10.3877/cma.j.issn.1674-134X.2023.05.015

综述

股骨头坏死细胞治疗的前景和挑战
卫杨文祥, 黄浩然, 刘予豪, 陈镇秋, 王海彬, 周驰†()   
  1. 510405　广州中医药大学第一临床医学院
    510405　广州中医药大学第一附属医院骨科
    510405　广州中医药大学第一附属医院骨科；525000　广州中医药大学茂名医院
  • 收稿日期:2022-06-10 出版日期:2023-10-01
  • 通信作者: 周驰
  • 基金资助:
    广东省普通高校特色创新项目(2021KTSCX021); 广州市科技局市（校）联合资助项目(202201020314)

Outlooks and challenges in cell therapy of osteonecrosis of femoral head

Yangwenxiang Wei, Haoran Huang, Yuhao Liu, Zhenqiu Chen, Haibin Wang, Chi Zhou†()   

  1. The First Clinical Medical College, Guangzhou University of ChineseMedicine, Guangzhou 510405, China
    Department of Joint Orthopaedic, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    Department of Joint Orthopaedic, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Guangzhou University of Chinese Medicine Maoming Hospital, Maoming 525000, China
  • Received:2022-06-10 Published:2023-10-01
  • Corresponding author: Chi Zhou
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引用本文：

卫杨文祥, 黄浩然, 刘予豪, 陈镇秋, 王海彬, 周驰. 股骨头坏死细胞治疗的前景和挑战[J]. 中华关节外科杂志(电子版), 2023, 17(05): 694-700.

Yangwenxiang Wei, Haoran Huang, Yuhao Liu, Zhenqiu Chen, Haibin Wang, Chi Zhou. Outlooks and challenges in cell therapy of osteonecrosis of femoral head[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 694-700.

股骨头坏死(ONFH)是一种病因复杂、发病机制不明确，且缺乏最佳治疗方法的进行性疾病。常导致髋关节疼痛以及功能障碍，主要见于中青年患者。目前对于ONFH的治疗多以促进成骨和成血管为主。然而单一的治疗只能对早期ONFH起到积极作用，并不能解决根本上的难题，即缺血环境下骨质的吸收与软骨下骨塌陷。随着现代医学技术的发展，细胞治疗ONFH已成为当下的研究热点。本文综述了现阶段干细胞在ONFH领域的相关疗效。越来越多的研究证实了干细胞治疗ONFH的有效性与可行性，但在实际应用中会遇到许多难题。因此，如何高效利用细胞治疗ONFH仍是当下的研究重点。

关键词: 细胞和组织治疗, 股骨头坏死, 间质干细胞, 综述

Osteonecrosis of the femoral head (ONFH) is a progressive disease with complex etiology, unclear pathogenesis and lack of optimal treatment.This diseases often causeship pain and functionalimpairment, and is mainlyseen in young and middle-aged patients. Current treatment for ONFH is mostly osteogenic and angiogenic. However, a single treatment can only have a positive effect on early ONFH and does not address the fundamental challenge, which is bone resorption and subchondral bone collapse in an ischemic environment. With the development of modern medicalt echnology, cell therapy for ONFH has become a hot topic of current research. This article reviewed the current therapeutic effects of stem cells in the field of ONFH. More and more studies have confirmed the efficacy and feasibility of stem cell therapy for ONFH. Therefore, the source, quantity and safety of the cells need to be further explored.

Key words: Cell therapy, Necrosis of femoral head, Mesenchymal stem cells, Review
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