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中华关节外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (06) : 842 -846. doi: 10.3877/cma.j.issn.1674-134X.2023.06.012

综述

微小RNA与全膝关节置换术后深静脉血栓的研究进展
闫文, 谢兴文, 顾玉彪(), 雷宁波, 马成, 于文霞, 高亚雄, 张磊   
  1. 730000 兰州,甘肃中医药大学
    730000 兰州,甘肃中医药大学附属医院
    730000 兰州,甘肃省中医院
  • 收稿日期:2022-08-04 出版日期:2023-12-01
  • 通信作者: 顾玉彪
  • 基金资助:
    国家自然科学基金项目(82160918); 兰州市人才创新创业项目(2021-RC-131)

Research progress of microRNA and deep vein thrombosis after total knee arthroplasty

Wen Yan, Xingwen Xie, Yubiao Gu(), Ningbo Lei, Cheng Ma, Wenxia Yu, Yaxiong Gao, Lei Zhang   

  1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
    Gansu University of Traditional Chinese Medicine Affiliated Hospital, Lanzhou 730000, China
    Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730000, China
  • Received:2022-08-04 Published:2023-12-01
  • Corresponding author: Yubiao Gu
引用本文:

闫文, 谢兴文, 顾玉彪, 雷宁波, 马成, 于文霞, 高亚雄, 张磊. 微小RNA与全膝关节置换术后深静脉血栓的研究进展[J/OL]. 中华关节外科杂志(电子版), 2023, 17(06): 842-846.

Wen Yan, Xingwen Xie, Yubiao Gu, Ningbo Lei, Cheng Ma, Wenxia Yu, Yaxiong Gao, Lei Zhang. Research progress of microRNA and deep vein thrombosis after total knee arthroplasty[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(06): 842-846.

全膝关节置换术作为膝骨关节炎后期唯一的治疗手段,主要通过为患者进行人工关节的置换来改善患者的临床症状。下肢深静脉血栓作为全膝关节置换术后常见的并发症也常常出现。笔者通过查阅大量现代医学研究文献发现相关微小RNA(microRNA)的表达与血栓的形成密切相关。microRNA通过调控相关的凝血因子、蛋白、细胞因子等,抑制血栓的形成,进而达到预防深静脉血栓的效果。本文通过microRNA与深静脉血栓形成的相关因素进行综述,以期对全膝关节置换术后深静脉血栓的预防提供一些新的指导,旨在为microRNA预防深静脉血栓的深入研究提供参考依据。

Total knee arthroplasty, as the only treatment in the late stage of knee osteoarthritis, mainly improves the clinical symptoms of patients by replacing artificial joints for patients. Deep vein thrombosis of the lower extremity is the most common complication of total knee arthroplasty. By consulting a large number of modern medical research literature, the author found that the expression of related microRNA is closely related to the formation of thrombus. By regulating related coagulation factors, proteins, cytokines, etc., microRNA inhibits the formation of thrombus, thereby achieving the effect of preventing deep vein thrombosis. This article reviewed the related factors of microRNA and deep vein thrombosis, in order to provide some new guidance for the prevention of deep vein thrombosis after total knee arthroplasty, aiming to provide a reference for the in-depth study of microRNA prevention of deep vein thrombosis.

图1 microRNA与TKA(全膝关节置换术)后DVT(深静脉血栓)的相关性
Figure 1 Relationship between microRNA and DVT after TKA
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