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中华关节外科杂志(电子版) ›› 2026, Vol. 20 ›› Issue (03) : 375 -380. doi: 10.3877/cma.j.issn.1674-134X.2026.03.015

临床经验

股骨头坏死长期保守治疗成功的系列特例观察与思考
江梓熙1, 郭庚灵1, 黄志强1, 黄香1, 戴雪梅2, 莫焕涛3, 李康活4, 陈镇秋2, 黄泽青2,()   
  1. 1 510405 广州中医药大学
    2 510405 广州中医药大学第一附属医院股骨头坏死科
    3 510405 广州中医药大学第一附属医院影像科
    4 528000 广东佛山,广州中医药大学顺德医院(佛山市顺德区中医院)关节与运动医学科
  • 收稿日期:2026-01-29 出版日期:2026-06-01
  • 通信作者: 黄泽青
  • 基金资助:
    国家自然科学基金(82205138); 广州中医药大学第一附属医院2023年医院中青年骨干人才培育项目; 广东省中医药局科研项目(20261120,20261122)

Observation and reflection on special cases series of successful long-term conservative treatment for osteonecrosis of femoral head

Zixi Jiang1, Gengling Guo1, Zhiqiang Huang1, Xiang Huang1, Xuemei Dai2, Huantao Mo3, Kanghuo Li4, Zhenqiu Chen2, Zeqing Huang2,()   

  1. 1 Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    2 Department of Osteonecrosis of the Femoral Head, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    3 Radiology Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    4 Department of Joint and Sports Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan 528000, China
  • Received:2026-01-29 Published:2026-06-01
  • Corresponding author: Zeqing Huang
引用本文:

江梓熙, 郭庚灵, 黄志强, 黄香, 戴雪梅, 莫焕涛, 李康活, 陈镇秋, 黄泽青. 股骨头坏死长期保守治疗成功的系列特例观察与思考[J/OL]. 中华关节外科杂志(电子版), 2026, 20(03): 375-380.

Zixi Jiang, Gengling Guo, Zhiqiang Huang, Xiang Huang, Xuemei Dai, Huantao Mo, Kanghuo Li, Zhenqiu Chen, Zeqing Huang. Observation and reflection on special cases series of successful long-term conservative treatment for osteonecrosis of femoral head[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2026, 20(03): 375-380.

目的

分析长期保守治疗成功的股骨头坏死病例特点,总结保守治疗股骨头坏死的临床经验。

方法

回顾性分析2009年10月至2024年10月于广州中医药大学第一附属医院接受保守治疗,且连续随访时间超过5年的股骨头坏死患者。记录患者国际骨循环研究协会(ARCO)分期、日本骨坏死研究会(JIC)分型、股骨头受累面积百分比,进行描述性分析。根据影像学转归特点,将病例分为长期稳定型、内侧塌陷型、软骨下骨折修复型。

结果

共纳入16例患者,随访时间8(7,12)年,其中长期稳定型10例,内侧塌陷型5例,软骨下骨折修复型1例。长期稳定型中,1例JIC C1型患者股骨头受累面积为轻度,3例股骨头受累面积为重度但病灶位于内侧(JIC A型),其余6例股骨头受累面积均为轻度或中度,JIC分型均为A或B型。5例内侧塌陷型股骨头受累面积均为重度,其中4例均观察到“塌陷-停止-修复”过程。软骨下骨折修复型1例为JIC C1型,股骨头受累面积为中度,外侧皮质保留,软骨下骨折线于8年内消失。

结论

JIC A和B型最适合进行保守治疗,通常能够获得长期稳定,即使坏死面积较大发生塌陷,也多趋于自限甚至修复,预后良好;JIC C1型患者若股骨头受累面积为轻度或中度,外侧皮质保留,仍有可能获得长期稳定甚至软骨下骨折修复,但鉴别较难,建议联合使用外侧壁保留角或中日友好医院分型进行量化评估。

Objective

To analyze the characteristics of patients with osteonecrosis of the femoral head (ONFH) who achieved long-term success with conservative treatment and to summarize clinical experience in the conservative management of ONFH.

Methods

A retrospective analysis was conducted on patients with ONFH who received conservative treatment at the First Affiliated Hospital of Guangzhou University of Chinese Medicine from October 2009 to October 2024, with a continuous follow-up of more than five years. The Association Research Circulation Osseous (ARCO) stage, Japanese Investigation Committee (JIC) classification, and percentage of femoral head involvement were recorded and descriptively analyzed. According to the imaging outcomes, the cases were classified into three types: long-term stable type, medial collapse type, and subchondral fracture repair type.

Results

A total of 16 patients were included, with a follow-up duration of 8 (7, 12) years. Among them, 10 cases were classified as long-term stable type, five as medial collapse type, and one as subchondral fracture repair type. In the long-term stable group, one patient with JIC type C1 had mild femoral head involvement, three patients had severe involvement but with lesions located medially (JIC type A), and the remaining six patients had mild or moderate involvement with JIC type A or B. All the five medial collapse cases had severe femoral head involvement, and four of them exhibited a "collapse-arrest-repair" process. The single subchondral fracture repair case was JIC type C1 with moderate femoral head involvement and preserved lateral cortex; the subchondral fracture line disappeared within eight years.

Conclusions

JIC types A and B are the most suitable candidates for conservative treatment, generally achieving long-term stability. Even when collapse occurs due to a large necrotic area, it tends to be self-limiting or even repair, with a favorable prognosis. For patients with JIC type C1, if the percentage of femoral head involvement is mild or moderate and the lateral cortex is preserved, long-term stability or even healing of subchondral fracture is still possible. However, identification is more difficult. It is recommended to combine quantitative assessments such as the preserved angle of the lateral wall or the China-Japan Friendship Hospital (CJFH) classification.

图1 长期稳定型ONFH(股骨头坏死)随访影像。图A~B为初诊右髋正位和蛙位X线片,示股骨头内侧高密度坏死灶,轮廓完整无塌陷;图C为随访第3个月双髋MRI T1冠状位中央层面,示右股骨头坏死病灶广泛;图D~E为随访第13年右髋正、蛙位X线片,股骨头仍保持轮廓完整,未见塌陷
Figure 1 Follow-up images of long-term stable ONFH (osteonecrosis of the femoral head). A and B are primary radiographs of right hip at anteroposterior (AP) and frog-leg lateral (FL) positions, showing high-density medial necrotic lesion with intact contour and no collapse; C is mid-slice image of coronal T1WI MRI of bilateral hips in the follow-up of three months, showing extensive necrosis in right femoral head; D and E are radiographs of right hip at AP and FL positions in the follow-up of 13 years, demonstrating intact contour without collapse
图2 内侧塌陷型ONFH(股骨头坏死)左髋正位和蛙位X线片。图A~B为初诊左髋正位和蛙位片,图A箭头示低密度囊变区;图C、D为随访第3年正位和蛙位片,图C箭头示病灶边缘高密度硬化带;图E~F为随访第8年正位和蛙位片,图E箭头示病灶沿硬化带塌陷下沉
Figure 2 Radiographs of left hip with medial collapse-type ONFH (osteonecrosis of the femoral head) at anteroposterior and frog-leg positions. A and B are primary images, the arrows indicating low-density cystic area; C and D are images in the follow-up of three years, arrows showing high-density sclerotic rim at lesion margin; E and F in the follow-up of eight years, arrows demonstrating collapse and subsidence along the sclerotic rim
图3 内侧塌陷型ONFH(股骨头坏死)随访影像。图A~B为初诊右髋正位和蛙位片,图A箭头示低密度断裂带,图B箭头示大面积囊变;图C为随访第1年CT冠状位图像,箭头示清晰内侧断裂带;图D为随访第1年MRI冠状位坏死最大层面图像,示右股骨头广泛坏死;图E~F为随访第2年正位和蛙位片,图E箭头示断裂带较图A收窄,图F示囊变区仍较大;图G~H为随访第7年正位和蛙位片,图G示原断裂带密度增高,图H箭头示囊变区密度增高
Figure 3 Follow-up images of medial collapse-type ONFH (osteonecrosis of the femoral head). A is primary radiograph of right hip at anteroposterior (AP) position, arrow showing low-density break line; B is primary radiograph of right hip at frog-leg lateral (FL) position, arrow showing extensive cysts; C is coronal CT image of bilateral hips at one year follow-up, arrow indicating clear medial break line; D is coronal MRI image of bilateral hips at one year follow-up in maximal lesion section, showing extensive necrosis; E and F are radiographs of right hip at AP and FL positions in two-year follow-up, the arrow in E showing narrowed break line compared to the primary one, the arrow in F showing remaining large cysts; G and H are radiographs of right hip at AP and FL positions in seven-year follow-up, showing increased density at original break line, the arrow indicates the increased cystic density
图4 软骨下骨折修复型ONFH(股骨头坏死)右髋正位和蛙位X线片。图A~B为初诊片,箭头示软骨下骨折线;图C~D为随访第4个月片,箭头示骨折线延长;图E~F为随访第1年X线片,示原骨折线消失,箭头示坏死病灶较前缩小;图G~H为随访第8年X线片,示原软骨下骨折区域密度增高,箭头示坏死病灶再次缩小
Figure 4 Radiographs of left hip with subchondral fracture repair-type ONFH (osteonecrosis of the femoral head) at anteroposterior and frog-leg positions. A and B are primary images, the arrow showing subchondral fracture line; C and D are images in the follow-up of four months, the arrow showing fracture line extension; E and F are images in the follow-up of one year showing that original fracture line disappeared, the arrow indicates decreased lesion size; G and H are images in the follow-up of eight years showing that increased density in original fracture area, the arrow indicates further shrinkage
[1]
孙伟, 高福强, 李子荣. 股骨头坏死临床诊疗技术专家共识(2022年)[J]. 中国修复重建外科杂志, 2022, 36(11): 1319-1326.
[2]
Zhao DW, Yu M, Hu K, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey[J]. Chin Med J, 2015, 128(21): 2843-2850.
[3]
Hernigou P, Poignard A, Nogier A, et al. Fate of very small asymptomatic stage-iosteonecrotic lesions of the hip[J]. J Bone Joint Surg Am, 2004, 86(12): 2589-2593.
[4]
Mont MA, Zywiel MG, Marker DR, et al. The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review[J]. J Bone Joint Surg Am, 2010, 92(12): 2165-2170.
[5]
Koo KH, Mont MA, Lynne C, et al. 骨坏死[M]. 孙伟 译. 北京: 人民军医出版社, 2015: 192.
[6]
Sugano N, Takaoka K, Ohzono K, et al. Prognostication of nontraumatic avascular necrosis of the femoral head: significance of location and size of the necrotic lesion[J/OL]. Clin Orthop Relat Res, 1994, 303: 155-164. DOI: 10.1097/00003086-199406000-00019.
[7]
Takashima K, Uemura K, Ando W, et al. Comparison of the 2021 association research circulation osseous classification system for osteonecrosis of the femoral head and the Japanese investigation committee classification system[J]. J Arthroplasty, 2025, 40(10S1): S21-S26.
[8]
Kuroda Y, Tanaka T, Miyagawa T, et al. Classification of osteonecrosis of the femoral head: Who should have surgery?[J]. Bone Jt Res, 2019, 8(10): 451-458.
[9]
Asada R, Abe H, Hamada H, et al. Femoral head collapse rate among Japanese patients with pre-collapse osteonecrosis of the femoral head[J/OL]. J Int Med Res, 2021, 49(6): 03000605211023336. DOI: 10.1177/03000605211023336.
[10]
Takashima K, Sakai T, Hamada H, et al. Which classification system is most useful for classifying osteonecrosis of the femoral head?[J]. Clin Orthop Relat Res, 2018, 476(6): 1240-1249.
[11]
Nishii T, Sugano N, Ohzono K, et al. Progression and cessation of collapse in osteonecrosis of the femoral head[J]. Clin Orthop Relat Res, 2002(400): 149-157.
[12]
颜新昊, 庞凤祥, 钟原, 等. 股骨头前、外侧壁保留角与股骨头坏死塌陷进展的相关性[J]. 中国组织工程研究, 2021, 25(36): 5827-5831.
[13]
Wei QS, Li ZQ, Hong ZN, et al. Predicting collapse in osteonecrosis of the femoral head using a new method: preserved angles of anterior and lateral femoral head[J]. J Bone Joint Surg, 2022, 104(Suppl 2): 47-53.
[14]
中国医师协会骨科医师分会骨循环与骨坏死专业委员会, 中华医学会骨科分会骨显微修复学组, 国际骨循环学会中国区. 中国成人股骨头坏死临床诊疗指南(2020)[J]. 中华骨科杂志, 2020, 40(20): 1365-1376.
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