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中华关节外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 464 -471. doi: 10.3877/cma.j.issn.1674-134X.2025.04.008

综述

骨髓间充质干细胞在激素性股骨头坏死发病机制的研究进展
林志强1,2, 李嘉欢1, 张凯1, 李文帅1, 刘健1, 邓泽群3, 乔永杰2, 周胜虎2,†()   
  1. 1730030　兰州，甘肃中医药大学
    2730050　兰州，解放军联勤保障部队第九四〇医院关节外科
    3750004　银川，宁夏医科大学
  • 收稿日期:2024-06-05 出版日期:2025-08-01
  • 通信作者: 周胜虎
  • 基金资助:
    甘肃省重点研发计划(25YFFA064); 甘肃省卫生健康行业科研(GS-62000000025-2024-068); 兰州市科技计划(2023-2-11); 甘肃中医药大学导师专项(2023YXKY015)

Progress of bone marrow mesenchymal stem cells in pathogenesis of hormonal femoral head necrosis

Zhiqiang Lin1,2, Jiahuan Li1, Kai Zhang1, Wenshuai Li1, Jian Liu1, Zequn Deng3, Yongjie Qiao2, Shenghu Zhou2,†()   

  1. 1Gansu University of Chinese Medicine, Lanzhou 730030, China
    2The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
    3Ningxia Medical University, Yinchuan 750004, China
  • Received:2024-06-05 Published:2025-08-01
  • Corresponding author: Shenghu Zhou
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引用本文：

林志强, 李嘉欢, 张凯, 李文帅, 刘健, 邓泽群, 乔永杰, 周胜虎. 骨髓间充质干细胞在激素性股骨头坏死发病机制的研究进展[J/OL]. 中华关节外科杂志(电子版), 2025, 19(04): 464-471.

Zhiqiang Lin, Jiahuan Li, Kai Zhang, Wenshuai Li, Jian Liu, Zequn Deng, Yongjie Qiao, Shenghu Zhou. Progress of bone marrow mesenchymal stem cells in pathogenesis of hormonal femoral head necrosis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(04): 464-471.

激素性股骨头坏死（SANFH）是一种代谢性疾病，由于持续服用高剂量的糖皮质激素（GCs），股骨头局部血液循环受阻，发生组织缺血、坏死等病变。SANFH具有高致残率，严重影响患者生存质量，但其具体发病机制尚未完全阐明。但研究表明，骨髓间充质干细胞（BMSCs）成骨和成脂分化的失衡是SANFH发生发展的主要机制之一。本文对BMSCs在SANFH发病机制中的研究进展进行综述，为进一步防治SANFH提供参考依据。

关键词: 间质干细胞, 糖皮质激素类, 股骨头坏死, 成骨细胞

Steroids induced avascular necrosis of femoral head (SANFH) is a metabolic disease in which ischaemia and necrosis of the femoral head occur as a result of obstruction of local blood circulation due to continuous administration of high doses of glucocorticoids (GCs). SANFH has a high disability rate, which seriously affects the quality of patients’ survival, but its specific pathogenesis has not been fully elucidated, among which the imbalance of osteogenic and lipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is considered to be one of the main mechanisms for the development of SANFH. The research progresses of BMSCs in the pathogenesis of SANFH were reviewed to provide a reference basis for further prevention and treatment of SANFH.

Key words: Mesenchymal stem cells, Glucocorticoids, Femoral head necrosis, Osteoblasts
图1 BMSCs（骨髓间充质干细胞）成骨、成脂分化的机制示意图
Figure 1 Schematic diagram of BMSCs (bone marrow mesenchymal stem cells) for osteogenic and lipogenic differentiation
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