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中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 383 -389. doi: 10.3877/cma.j.issn.1674-134X.2024.03.012

综述

股骨头坏死动物模型研究进展
田志敏1, 何淳诺1, 李焕玺1, 吴昊越2, 刘鹏3, 乔永杰3, 周胜虎3, 蓝平衡4, 郭氧4, 张浩强3,()   
  1. 1. 730000 兰州,解放军联勤保障部队第九四〇医院关节外科;730000 兰州,甘肃中医药大学第一临床医学院
    2. 730000 兰州,解放军联勤保障部队第九四〇医院关节外科;750000 银川,宁夏医科大学
    3. 730000 兰州,解放军联勤保障部队第九四〇医院关节外科
    4. 361003 厦门大学第一附属医院骨科
  • 收稿日期:2023-12-26 出版日期:2024-06-01
  • 通信作者: 张浩强
  • 基金资助:
    甘肃省自然科学基金项目(22JR5RA009); 福建省自然科学基金项目(2020J05007); 兰州市科技计划项目(2023-2-28); 第九四〇医院院内科研基金(2023YXKY036); 厦门市医疗卫生指导性项目(3502Z20209264)

Advances in animal models of femoral head necrosis

Zhimin Tian1, Chunnuo He1, Huanxi Li1, Haoyue Wu2, Peng Liu3, Yongjie Qiao3, Shenghu Zhou3, Pingheng Lan4, Yang Guo4, Haoqiang Zhang3,()   

  1. 1. Department of Joint Surgery, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730000, China;The First Clinical College of Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
    2. Department of Joint Surgery, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730000, China;Ningxia Medical University, Yinchuan 750000, China
    3. Department of Joint Surgery, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730000, China
    4. Department of Orthopaedics, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China
  • Received:2023-12-26 Published:2024-06-01
  • Corresponding author: Haoqiang Zhang
引用本文:

田志敏, 何淳诺, 李焕玺, 吴昊越, 刘鹏, 乔永杰, 周胜虎, 蓝平衡, 郭氧, 张浩强. 股骨头坏死动物模型研究进展[J/OL]. 中华关节外科杂志(电子版), 2024, 18(03): 383-389.

Zhimin Tian, Chunnuo He, Huanxi Li, Haoyue Wu, Peng Liu, Yongjie Qiao, Shenghu Zhou, Pingheng Lan, Yang Guo, Haoqiang Zhang. Advances in animal models of femoral head necrosis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(03): 383-389.

股骨头坏死的发病机制复杂多样,大多数早期股骨头坏死患者未能得到及时、有效的诊疗,疾病进展导致股骨头塌陷和髋关节骨关节炎。为了研究股骨头坏死的发病机制和治疗方式,众多学者在股骨头坏死动物实验模型方面做了大量研究。但目前仍缺乏与临床实际相匹配的动物模型,使得许多有争议的临床问题无法通过动物实验有效验证并解决。本文对国内外股骨头坏死动物造模方法进行归纳整理,分析各种动物模型的优缺点,从中了解动物造模的最新发展为后续模型选择和改进提供参考和方向。

The pathogenesis of femoral head necrosis (ONFH) is complex and diverse, and most patients with initial-stage ONFHdo not receive prompt and effective diagnosis and treatment, which leads to femoral head collapse and osteoarthritis in the hip joint consequently. Numerous scholars have extensively researched the pathogenesis and treatment of ONFH by utilizing animal experimental models. However, there is still a lack of animal models that match clinical reality, which means many controversial clinical issues cannot be effectively verified and solved by animal experiments. This paper aimed to provide an overview of animal modeling in ONFH, and evaluate the advantages and disadvantages of the animal models, in order to understand the latest development of animal modeling and provide reference and direction for the subsequent selection and improvement of ONFH animal models.

图1 文献检索流程图
Figure 1 Flowchart of literature retrieval
表1 各种类型ONFH优缺点及成功率
Table 1 Advantages and disadvantages and success rate of various types of ONFH
表2 ONFH动物选择
Table 2 ONFH animal selection
表3 ONFH造模后评价方法
Table 3 Evaluation method of ONFH after molding
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