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中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (04) : 437 -442. doi: 10.3877/cma.j.issn.1674-134X.2019.04.009

所属专题: 文献

荟萃研究

代谢综合征与骨关节炎相关性的Meta分析
庄腾丰1, 郑小飞1, 刘宁1, 侯辉歌1, 郇松玮1, 王圣淳1, 王华军1,(), 查振刚1   
  1. 1. 510630 广州,暨南大学附属第一医院骨关节与运动医学科
  • 收稿日期:2018-05-19 出版日期:2019-08-01
  • 通信作者: 王华军
  • 基金资助:
    中国博士后科学基金资助项目(2015M582480,2017T100660); 广东省自然科学基金项目(2016A030313100); 国家自然科学基金项目(81601219)

Meta analysis on correlation between metabolic syndrome and osteoarthritis

Tengfeng Zhuang1, Xiaofei Zheng1, Ning Liu1, Huige Hou1, Songwei Huan1, Shengchun Wang1, Huajun Wang1,(), Zhengang Zha1   

  1. 1. Department of bone and joint surgery, the First Affilated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2018-05-19 Published:2019-08-01
  • Corresponding author: Huajun Wang
  • About author:
    Corresponding author: Wang Huajun, Email:
引用本文:

庄腾丰, 郑小飞, 刘宁, 侯辉歌, 郇松玮, 王圣淳, 王华军, 查振刚. 代谢综合征与骨关节炎相关性的Meta分析[J]. 中华关节外科杂志(电子版), 2019, 13(04): 437-442.

Tengfeng Zhuang, Xiaofei Zheng, Ning Liu, Huige Hou, Songwei Huan, Shengchun Wang, Huajun Wang, Zhengang Zha. Meta analysis on correlation between metabolic syndrome and osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(04): 437-442.

目的

系统评价代谢综合征与骨关节炎发病风险的相关性。

方法

通过检索Pubmed,荷兰医学文摘数据库(EMbase),中国生物医学文献数据库(CBM),维普网(VIP), Cochrane图书馆(2018年第5期),中国知网(CNKI),万方(WanFang)等电子数据库,搜集代谢综合征对骨关节炎(OA)发生风险相关性的观察性研究,检索时间均为自建库至2018年5月。由2位作者按照纳入、排除标准(探讨代谢综合征与骨关节炎的相关性为研究主题的观察性研究,并排除重复发表的文献)独立甄选文献、计算数据并进行纳入研究的质量评估后,运用Revman 5.3软件进行Meta分析。

结果

最终纳入9篇文献,总共25 096例患者。原始比值比(OR)及95%置信区间(CI)的Meta分析结果显示,患有代谢综合征人群的骨关节炎发病风险是未患代谢综合征人群的2.23倍[OR =2.23,95%CI(1.48,3.36),P=0.000 1],校正后的Meta分析结果仍然显示患有代谢综合征人群的骨关节炎发病风险高于未患代谢综合征人群[OR=1.05,95%CI(1.03,1.07),P<0.01]。

结论

代谢综合征与骨关节炎发病具有相关性,代谢综合征可增加骨关节炎的发病风险。

Objective

To systematically assess the relationship between metabolic syndrome and osteoarthritis.

Methods

Databases including PubMed, Excerpta Medica Database(EMbase), China Biology Medicine disc (CBM), China Science and Technology Journal Database(VIP), the Cochrane Library(Issue 5, 2018), China National Knowledge Infrastructure (CNKI) and WanFang Data were searched for the published studies including the investigation of the correlation between metabolic syndrome and osteoarthritis from inception to May 2018. The observational trials about correlation between metabolic syndrome and osteoarthritis were included, and repeat published literatures were excluded. Two authors specifically assessed literature according to the inclusion and exclusion criteria, acquired data and evaluated the risk of bias of involved studies. Meta-analysis was performed using RevMan 5.3 software.

Results

A total of nine studies including 25 096 patients were involved. The results of meta-analysis showed that pooled crude risk of occurrence of osteoarthritis in metabolic syndrome population was 2.23 times of the non-metabolic-syndrome population[OR=2.23, 95%CI(1.48, 3.36), P=0.0001], and pooled adjusted risk of occurrence of osteoarthritis in metabolic syndrome population was still greater than non-metabolic-syndrome population[OR=1.05, 95%CI(1.03, 1.07), P<0.01].

Conclusion

Metabolic syndrome is associated with osteoarthritis, which increases risk of osteoarthritis.

图1 文献筛选流程及结果
表1 纳入文献的基本情况
图2 代谢综合征与骨关节炎发病相关性的森林图,示原始OR(比值比)及95%CI(置信区间)
图3 代谢综合征与骨关节炎发病相关性的森林图,示校正OR(比值比)及95%CI(置信区间)
图4 代谢综合征与骨关节炎的发病相关性的Meta分析
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