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中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (04) : 443 -447. doi: 10.3877/cma.j.issn.1674-134X.2019.04.010

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综述

血小板抗感染的机制研究进展
张昭远1, 杨帆1, 卢年芳2, 袁霆1, 张长青1,()   
  1. 1. 200233 上海交通大学附属第六人民医院骨科
    2. 100073 北京电力医院重症医学科
  • 收稿日期:2018-10-22 出版日期:2019-08-01
  • 通信作者: 张长青
  • 基金资助:
    国家自然科学基金(81572239); 上海申康医院发展中心临床科技创新项目(SHDC12016219)

Research progress of anti-infective mechanism of platelets

Zhaoyuan Zhang1, Fan Yang1, Nianfang Lu2, Ting Yuan1, Changqing Zhang1,()   

  1. 1. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
    2. Intensive Care Unit, Beijing Electric Power Hospital, Beijing 100073, China
  • Received:2018-10-22 Published:2019-08-01
  • Corresponding author: Changqing Zhang
  • About author:
    Corresponding author: Zhang Changqing, Email:
引用本文:

张昭远, 杨帆, 卢年芳, 袁霆, 张长青. 血小板抗感染的机制研究进展[J/OL]. 中华关节外科杂志(电子版), 2019, 13(04): 443-447.

Zhaoyuan Zhang, Fan Yang, Nianfang Lu, Ting Yuan, Changqing Zhang. Research progress of anti-infective mechanism of platelets[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(04): 443-447.

感染是影响人类健康的常见疾病之一,可造成创面不愈合、脓毒症及其他感染性疾病,继而引发多系统器官衰竭而导致死亡。血小板是最常见的血液成分之一,最先发现内皮细胞损伤和病原微生物入侵并产生反应,可内吞病原体、释放抗菌肽和调节机体的免疫反应等。本文就血小板的抗感染机制研究进展作一综述。

Infection is one of the most common diseases, which can cause nonhealing wound, sepsis and other infectious diseases, then lead to multisystem organ failure and death. Platelets, one of the most common element of blood, is the first component which detect damage of endothelial cell and invasion of pathogen. In addition, platelets can internalize pathogens, secrete antimicrobial peptides, participate in and orchestrate the immune response. In this article, the research progress of anti-infective mechanism of platelets is reviewed.

图2 血小板在白细胞抗感染中的作用机制示意图。血小板通过P-selectin(选择素)与白细胞表面的PSGL-1(P选择素糖蛋白配法)结合,从而粘附于白细胞,形成花环样结构,并释放IL(白介素)-1、β-TG(血小板球蛋白)、PAF(血小板活化因子)等激活白细胞。白细胞被激活后,可吞噬病原体、产生脱颗粒效应(释放超氧化物和溶酶体酶,清除侵入体内的病原微生物)和形成NETs(中性粒细胞胞外诱捕网)
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