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中华关节外科杂志(电子版)

中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 209 -214. doi: 10.3877/cma.j.issn.1674-134X.2024.02.008

综述

辅助性T细胞17/调节性T细胞平衡在骨关节炎的作用
赵俊杰1, 王玺玉1, 黄鹏飞1, 张兆坤1, 蒲彦川2, 赵海燕1,†()   
  1. 1. 730000　兰州大学第一临床医学院；730000　兰州大学第一医院骨科
    2. 730000　兰州大学第一临床医学院；733000　甘肃省武威市人民医院骨科
  • 收稿日期:2023-11-17 出版日期:2024-04-01
  • 通信作者: 赵海燕
  • 基金资助:
    国家自然科学基金项目(82060394); 兰州市人才创新创业项目(2020-RC-45); 州大学第一医院院内基金(ldyyyn2022-73)

Research progress on role of T helper cell 17/ regulatory T cells balance in osteoarthritis

Junjie Zhao1, Xiyu Wang1, Pengfei Huang1, Zhaokun Zhang1, Yanchuan Pu2, Haiyan Zhao1,†()   

  1. 1. The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China; Department of Orthopaedics, The First Hospital of Lanzhou University, Lanzhou 730000, China
    2. The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China; Department of Orthopaedics, Wuwei People’s Hosptial, Wuwei 733000, China
  • Received:2023-11-17 Published:2024-04-01
  • Corresponding author: Haiyan Zhao
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赵俊杰, 王玺玉, 黄鹏飞, 张兆坤, 蒲彦川, 赵海燕. 辅助性T细胞17/调节性T细胞平衡在骨关节炎的作用[J]. 中华关节外科杂志(电子版), 2024, 18(02): 209-214.

Junjie Zhao, Xiyu Wang, Pengfei Huang, Zhaokun Zhang, Yanchuan Pu, Haiyan Zhao. Research progress on role of T helper cell 17/ regulatory T cells balance in osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(02): 209-214.

骨关节炎是世界上最常见的关节疾病，是以关节软骨破坏、滑膜炎症和软骨下骨重塑为特征的慢性炎症性疾病，骨免疫失调在骨关节炎的发病机制中也得到了充分的认识。辅助性T细胞17(Th17)和调节性T细胞(Treg)作为重要的免疫细胞在维持免疫自稳中发挥重要作用。Th17细胞可以通过促进骨吸收、造成软骨降解、加重滑膜炎症导致骨关节炎的进展，而Treg细胞则可以促进成骨、抑制炎症缓解骨关节炎。Th17细胞和Treg细胞之间存在着紧密的平衡关系，并且Th17/Treg细胞的失衡会加重骨关节炎病情。因此，本文对Th17/Treg细胞平衡在骨关节炎中的研究进展进行综述，有望为骨关节炎的免疫调节治疗提供新的治疗思路。

关键词: 骨关节炎, T淋巴细胞，调节性, Th17细胞

Osteoarthritis, the most prevalent joint disease on a global scale, is a persistent inflammatory ailment characterized by the deterioration of articular cartilage, inflammation of the synovial membrane, and remodeling of the bone beneath the cartilage surface. Moreover, immune-related dysfunctions in the bone have also been associated with the development of osteoarthritis. T helper cell 17 (Th17) and regulatory T cells (Treg), both vital components of the immune system, play a crucial role in maintaining the equilibrium of immune responses. Th17 cells have the ability to stimulate the breakdown of bone, which consequently leads to cartilage degradation and exacerbated inflammation of the synovial membrane, thereby contributing to the advancement of osteoarthritis. Conversely, Treg cells have the ability to promote bone formation, inhibit inflammation, and alleviate symptoms associated with osteoarthritis. Maintaining a balance between Th17 and Treg cells is of utmost importance, as an imbalance in the ratio of Th17 to Treg cells can further deteriorate the condition of osteoarthritis. As a result, this manuscript offered a comprehensive overview of the current state of research pertaining to the equilibrium between Th17 and Treg cells in osteoarthritis, with the intention of providing novel insights for the development of immunomodulatory treatments for this condition.

Key words: Osteoarthritis, T-Lymphocytes, regulatory, Th17 cells
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