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中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 372 -378. doi: 10.3877/cma.j.issn.1674-134X.2024.03.010

综述

二甲双胍治疗骨关节炎的机制及其研究进展
王颉1, 周游1,()   
  1. 1. 443001 宜昌,三峡大学附属仁和医院骨科,三峡大学运动医学研究所,宜昌市运动损伤与修复临床医学研究中心
  • 收稿日期:2023-12-09 出版日期:2024-06-01
  • 通信作者: 周游
  • 基金资助:
    湖北省自然科学基金面上项目(2021CFB414); 湖北省卫生健康委员会中医药科研项目(ZY2021M074)

Mechanism and research progress of metformin in treatment of osteoarthritis

Jie Wang1, You Zhou1,()   

  1. 1. Department of Orthopedics, Affiliated Renhe Hospital of China Three Gorges University & Sports Medicine Research Institute of China Three Gorges University & Clinical Medical Research Center of Yichang Sports Injury and repair, Yichang 443001, China
  • Received:2023-12-09 Published:2024-06-01
  • Corresponding author: You Zhou
引用本文:

王颉, 周游. 二甲双胍治疗骨关节炎的机制及其研究进展[J]. 中华关节外科杂志(电子版), 2024, 18(03): 372-378.

Jie Wang, You Zhou. Mechanism and research progress of metformin in treatment of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(03): 372-378.

骨关节炎(OA)是一种常见的关节退行性疾病,全球患病率和发病率日益增加,严重影响着人们的健康和生活。高龄、肥胖和关节损伤是OA常见的危险因素。OA与二型糖尿病(T2DM)关系密切,而高龄和肥胖是OA与T2DM共同的危险因素。二甲双胍是临床用于治疗T2DM的一线药物,也被认为是治疗OA的潜在药物,但作用机制尚未完全阐明。已知二甲双胍主要通过激活一磷酸腺苷依赖的蛋白激酶(AMPK),起到减轻慢性炎症、促进软骨修复的作用。现就二甲双胍治疗OA的机制及其研究进展进行综述。

Osteoarthritis(OA) is a common joint degenerative disease, the global prevalence and incidence rate is increasing, seriously affecting people's health and life. Advanced age, obesity and joint injury are common risk factors for OA. There is a close relationship between OA and type 2 diabetes mellitus(T2DM), and advanced age and obesity are common risk factors for OA and T2DM. Metformin is a clinical first-line drug for the treatment of T2DM, and it is also considered as a potential drug for the treatment of OA, but the mechanism has not been fully elucidated. It is known that metformin can reduce chronic inflammation and promote cartilage repair mainly by activating adenosine 5'-monophosphate activated protein kinase(AMPK). This article reviewed the mechanism and research progress of metformin in the treatment of OA.

图1 二甲双胍治疗OA的机制(参考自Chen等4 注:OA-骨关节炎;T2DM-二型糖尿病;Age-年龄;Obesity-肥胖;Joint injury-关节损伤;Osteoporosis-骨质疏松;Inflammation-炎症反应;Metformin-二甲双胍;OCT1-有机阳离子转运蛋白1;AMP-单磷酸腺苷;ATP-三磷酸腺苷;Complex 1-线粒体呼吸链复合物;JAK/STAT-Janus激酶信号转导和转录激活因子;IL-6-白细胞介素-6;TNF-α-肿瘤坏死因子-α;AMPK-一磷酸腺苷活化蛋白激酶;mTOR-哺乳动物雷帕霉素靶蛋白;AGEs-晚期糖基化终末产物;NF-κB-核因子κB;Autophagy-自噬;T-cell-T细胞;ER stress-内质网应激;ROS-活性氧;Qxidative stress-氧化应激;Hyperglycaemia-高血糖;Cartilage-软骨
Figure 1 The mechanism of metformin in the treatment of osteoarthritis
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