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中华关节外科杂志(电子版) ›› 2026, Vol. 20 ›› Issue (04) : 488 -493. doi: 10.3877/cma.j.issn.1674-134X.2026.04.011

综述

超声联合纳米颗粒靶向治疗骨关节炎的研究进展
祁秀1, 麻凌峰2, 栗平3,†()   
  1. 1 010020 呼和浩特市第二医院超声科
    2 528308 广东 佛山,南方医科大学顺德医院(佛山市顺德区第一人民医院)超声科
    3 010030 呼和浩特市,内蒙古医科大学第二附属医院超声科
  • 收稿日期:2026-01-23 出版日期:2026-08-01
  • 通信作者: 栗平
  • 基金资助:
    内蒙古自治区自然科学基金项目(2023LHMS08053)

Progress of ultrasound combined with nanoparticle-targeted therapy for osteoarthritis

Xiu Qi1, Lingfeng Ma2, Ping Li†,3()   

  1. 1Department of Ultrasound, Hohhot Second Hospital, Hohhot 010020, China
    2Department of Ultrasound, Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde), Foshan 528308, China
    3Department of Ultrasound, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
  • Received:2026-01-23 Published:2026-08-01
  • Corresponding author: Ping Li
引用本文:

祁秀, 麻凌峰, 栗平. 超声联合纳米颗粒靶向治疗骨关节炎的研究进展[J/OL]. 中华关节外科杂志(电子版), 2026, 20(04): 488-493.

Xiu Qi, Lingfeng Ma, Ping Li. Progress of ultrasound combined with nanoparticle-targeted therapy for osteoarthritis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2026, 20(04): 488-493.

骨关节炎(OA)是目前最常见的关节炎类型,目前超声引导治疗OA是一种重要的治疗方式。经超声引导的关节腔药物注射及病变区域的神经射频消融术可以有效地缓解OA患者慢性关节疼痛。同时,使用纳米颗粒载药靶向治疗OA也具有独特的治疗优势,其中的仿生纳米颗粒兼具更好的靶向能力以及超声显像能力,可以通过超声可视化监测仿生纳米颗粒载体内的靶向进程及药物释放程度。本文对超声引导下OA的关节腔药物注射和射频消融术等常规治疗,以及可视化监测下的纳米靶向治疗进展,涵盖金属纳米颗粒、聚合物纳米颗粒和仿生纳米颗粒三类载体作一综述。旨在为未来临床研究超声引导纳米颗粒靶向治疗OA提供更多的治疗思路,为临床提供更完善的治疗方案。

Osteoarthritis (OA) is currently the most common type of arthritis, and ultrasound-guided treatment for OA is an important therapeutic approach. Ultrasound-guided intra-articular drug injections and radiofrequency ablation of the affected areas can effectively relieve chronic joint pain in patients with OA. At the same time, targeted therapy for OA using drug-loaded nanoparticles offers unique therapeutic advantages. Among these, biomimetic nanoparticles combine superior targeting capabilities with ultrasonic imaging capabilities, allowing for ultrasonic visualization to monitor the targeting process and the extent of drug release within the biomimetic nanoparticle carriers. This article reviewed conventional treatments for OA—such as ultrasound-guided intra-articular drug injections and radiofrequency ablation—as well as advances in nanotargeted therapy under visual monitoring, covering three types of carriers: metal nanoparticles, polymer nanoparticles, and biomimetic nanoparticles. The aim is to provide additional therapeutic insights for future clinical research on ultrasound-guided nanotargeted therapy for OA and to offer more comprehensive treatment options for clinical practice.

图1 骨关节炎疾病过程示意图
Figure 1 Schematic diagram of the disease progression of osteoarthritis
图2 超声监测纳米颗粒载药靶向治疗OA(骨关节炎)示意图
Figure 2 Schematic illustration of ultrasound-guided targeted therapy for OA (osteoarthritis) using nanoparticle-bearing drugs
[1]
Siddiq MAB, Oo WM, Hunter DJ. New therapeutic strategies in osteoarthritis[J/OL]. Joint Bone Spine, 2024, 91(6): 105739. DOI: 10.1016/j.jbspin.2024.105739.
[2]
Minnig MCC, Golightly YM, Nelson AE. Epidemiology of osteoarthritis: literature update 2022-2023[J]. Curr Opin Rheumatol, 2024, 36(2): 108-112.
[3]
郑辉, 罗雍猷, 谢登辉, 等. 长链非编码RNA H19影响骨关节炎中骨软骨代谢的研究进展[J/OL]. 中华关节外科杂志(电子版), 2021, 15(6): 693-699.
[4]
Litwic A, Edwards MH, Dennison EM, et al. Epidemiology and burden of osteoarthritis[J]. Br Med Bull, 2013, 105: 185-199.
[5]
Roemer FW, Guermazi A, Demehri S, et al. Imaging in osteoarthritis[J]. Osteoarthr Cartil, 2022, 30(7): 913-934.
[6]
Bodor M, Uribe Y, Srikumaran U. Ultrasonic aspiration for vaccination-related shoulder dysfunction[J/OL]. Heliyon, 2021, 7(11): e08442. DOI: 10.1016/j.heliyon.2021.e08442.
[7]
王信亭, 胡月, 曾立志, 等. 超声引导下针刀联合药物注射治疗膝骨关节炎[J]. 中国临床研究, 2022, 35(6): 805-809.
[8]
Polat OE, Kokar S. Fluoroscopic confirmation of needle location in ultrasound-guided genicular nerve radiofrequency thermocoagulation[J]. Pain Physician, 2023, 26(6): E703-E711.
[9]
Mao L, Wu W, Wang M, et al. Targeted treatment for osteoarthritis: drugs and delivery system[J]. Drug Deliv, 2021, 28(1): 1861-1876.
[10]
Qin Y, Geng X, Sun Y, et al. Ultrasound nanotheranostics: Toward precision medicine[J]. J Control Release, 2023, 353: 105-124.
[11]
Deng X, Li Y, Li D. Ultrasound-guided versus blind arthrocentesis in knee osteoarthritis: a systematic review and meta-analysis[J/OL]. Medicine (Baltimore), 2025, 104(5): e41389. DOI: 10.1097/MD.0000000000041389.
[12]
Brookes PA, Stynes S. In patients with painful hip osteoarthritis, is it more beneficial to offer them an ultrasound-guided or a fluoroscopic-guided intra-articular corticosteroid injection to relieve their symptoms? a systematic review and network meta-analysis[J/OL]. Musculoskelet Care, 2024, 22(4): e70005. DOI: 10.1002/msc.70005.
[13]
Bernetti A, Agostini F, Finamore N, et al. Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: a systematic review[J]. J Back Musculoskelet Rehabil, 2025, 38(1): 19-47.
[14]
Zhao H, Hou YL, Guo LH, et al. Comparing ultrasound-guided intra-articular injection and medial branch block for lumbar facet joint pain: a clinical study[J/OL]. Diagn Interv Radiol, 2025, 31(3): 259-263. DOI: 10.4274/dir.2024.242765.
[15]
Paskins Z, Bromley K, Lewis M, et al. Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial[J/OL]. BMJ, 2022, 377: e068446. DOI: 10.1136/bmj-2021-068446.
[16]
Hsieh RL, Lee WC. Effects of intra-articular coinjections of hyaluronic acid and hypertonic dextrose on knee osteoarthritis: a prospective, randomized, double-blind trial[J]. Arch Phys Med Rehabil, 2022, 103(8): 1505-1514.
[17]
Nouri F, Babaee M, Peydayesh P, et al. Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial[J/OL]. BMC Musculoskelet Disord, 2022, 23(1): 856. DOI: 10.1186/s12891-022-05787-8.
[18]
Correia R, Oliveira L, Andrade I, et al. Ultrasound-guided radiofrequency ablation for chronic hip pain due to osteoarthritis[J/OL]. Cureus, 2024, 16(2): e53743. DOI: 10.7759/cureus.53743.
[19]
Elemam EM, Abdel Dayem OT, Mousa SA, et al. Ultrasound-guided monopolar versus bipolar radiofrequency ablation for genicular nerves in chronic knee osteoarthritis pain: a randomized controlled study[J/OL]. Ann Med Surg(Lond), 2022, 77: 103680. DOI: 10.1016/j.amsu.2022.103680.
[20]
Chang YW, Tzeng I-S, Lee K-C, et al. Functional outcomes and physical performance of knee osteoarthritis patients after ultrasound-guided genicular nerve radiofrequency ablation[J]. Pain Med, 2022, 23(2): 352-361.
[21]
Ma Y, Chen YS, Liu B, et al. Ultrasound-guided radiofrequency ablation for chronic osteoarthritis knee pain in the elderly: a randomized controlled trial[J]. Pain Physician, 2024, 27(3): 121-128.
[22]
Park EH, Fritz J. The role of imaging in osteoarthritis[J/OL]. Best Pract Res Clin Rheumatol, 2023, 37(2): 101866. DOI: 10.1016/j.berh.2023.101866.
[23]
Liang Q, Cheng Z, Qin L. Advanced nanoparticles in osteoarthritis treatment[J]. Biomater Transl, 2024, 5(2): 95-113.
[24]
Wei P, Cornel EJ, Du J. Ultrasound-responsive polymer-based drug delivery systems[J]. Drug Deliv Transl Res, 2021, 11(4): 1323-1339.
[25]
Han X, Xu K, Taratula O, et al. Applications of nanoparticles in biomedical imaging[J]. Nanoscale, 2019, 11(3): 799-819.
[26]
Luo J, Zhang Y, Zhu S, et al. The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis[J]. Naunyn Schmiedebergs Arch Pharmacol, 2021, 394(10): 1991-2002.
[27]
Shi T, Zhao J, Long K, et al. Cationic mesoporous silica nanoparticles alleviate osteoarthritis by targeting multiple inflammatory mediators[J/OL]. Biomaterials, 2023, 303: 122366. DOI: 10.1016/j.biomaterials.2023.122366.
[28]
Dos Santos Haupenthal DP, Resmini MB, da Silva LA, et al. Intra-articular treatment with triamcinolone hexacetonide associated with gold nanoparticles reduces cartilage degeneration in an animal model of osteoarthritis[J]. Curr Drug Targets, 2023, 24(3): 287-296.
[29]
Wang X, Cai Y, Wu C, et al. Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy[J/OL]. J Nanobiotechnology, 2023, 21(1): 258. DOI: 10.1186/s12951-023-02036-5.
[30]
Li S, He N, Wu X, et al. Characteristics of ultrasound-driven barium titanate nanoparticles and the mechanism of action on solid tumors[J]. Int J Nanomedicine, 2024, 19: 12769-12791.
[31]
Shen J, Shi W, Liu G, et al. Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging[J]. J Mater Chem B, 2023, 11(25): 5777-5785.
[32]
Kim EH, Park S, Bae ON. Cardiovascular toxicity of metal-based nanoparticles[J/OL]. Int J Mol Sci, 2025, 26(12): 5816. DOI: 10.3390/ijms26125816.
[33]
Tripathy DB, Pradhan S, Gupta A, et al. Nanoparticles induced neurotoxicity[J]. Nanotoxicology, 2025, 19(3): 325-352.
[34]
Mei H, Sha C, Lv Q, et al. Multifunctional polymeric nanocapsules with enhanced cartilage penetration and retention for osteoarthritis treatment[J]. J Control Release, 2024, 374: 466-477.
[35]
Ma JC, Luo T, Feng B, et al. Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy[J/OL]. J Nanobiotechnology, 2023, 21(1): 361. DOI: 10.1186/s12951-023-02118-4.
[36]
Zhao Y, Deng X, Tan S, et al. Co-polymer carrier with dual advantages of cartilage-penetrating and targeting improves delivery and efficacy of microRNA treatment of osteoarthritis[J/OL]. Adv Healthc Mater, 2023, 12(6): e2202143. DOI: 10.1002/adhm.202202143.
[37]
Pontes-Quero GM, Benito-Garzón L, Pérez Cano J, et al. Modulation of inflammatory mediators by polymeric nanoparticles loaded with anti-inflammatory drugs[J/OL]. Pharmaceutics, 2021, 13(2): 290. DOI: 10.3390/pharmaceutics13020290.
[38]
Baharizade M, Ghetmiri SI, Mohammady M, et al. Revolutionizing knee osteoarthritis treatment: innovative self-nano-emulsifying polyethylene glycol organogel of curcumin for effective topical delivery[J/OL]. AAPS PharmSciTech, 2024, 25(4): 80. DOI: 10.1208/s12249-024-02789-8.
[39]
Sridharan B, Lim HG. Advances in photoacoustic imaging aided by nano contrast agents: special focus on role of lymphatic system imaging for cancer theranostics[J/OL]. J Nanobiotechnology, 2023, 21(1): 437. DOI: 10.1186/s12951-023-02192-8.
[40]
Li Q, Sun T, Liu S, et al. Overview of biomembrane-derived nanoparticles as emerging drug delivery systems for treating bone aging diseases[J/OL]. Int J Pharm, 2025, 681: 125832. DOI: 10.1016/j.ijpharm.2025.125832.
[41]
Jugniot N, Massoud TF, Dahl JJ, et al. Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging[J/OL]. J Nanobiotechnology, 2022, 20(1): 267. DOI: 10.1186/s12951-022-01484-9.
[42]
Zhang Y, Wang J. Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells[J/OL]. Front Oncol, 2024, 14: 1389775. DOI: 10.3389/fonc.2024.1389775.
[43]
Liao J, Zhu Z, Zou J, et al. Macrophage membrane-biomimetic multi-layered nanoparticles targeting synovial angiogenesis for osteoarthritis therapy[J/OL]. Adv Healthc Mater, 2025, 14(2): 2401985. DOI: 10.1002/adhm.202401985.
[44]
Zhou K, Yang C, Shi K, et al. Activated macrophage membrane-coated nanoparticles relieve osteoarthritis-induced synovitis and joint damage[J/OL]. Biomaterials, 2023, 295: 122036. DOI: 10.1016/j.biomaterials.2023.122036.
[45]
Deng R, Zhao R, Zhang Z, et al. Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis[J/OL]. Sci Transl Med, 2024, 16(735): eadh9751. DOI: 10.1126/scitranslmed.adh9751.
[46]
Yu Q, Huang Y, Chen X, et al. A neutrophil cell membrane-biomimetic nanoplatform based on L-arginine nanoparticles for early osteoarthritis diagnosis and nitric oxide therapy[J]. Nanoscale, 2022, 14(32): 11619-11634.
[47]
Teo KYW, Sevencan C, Cheow YA, et al. Macrophage polarization as a facile strategy to enhance efficacy of macrophage membrane-coated nanoparticles in osteoarthritis[J/OL]. Small Sci, 2022, 2(4): 2100116. DOI: 10.1002/smsc.202100116.
[48]
王煜, 李朝, 王为婧, 等. 仿生双模态肿瘤靶向纳米气泡超声造影剂的制备及其功能[J]. 中国医学影像学杂志, 2024, 32(6): 533-538.
[49]
Hu W, Li M, Feng Y, et al. Molecular imaging for biomimetic nanomedicine in cancer therapy: current insights and challenges[J]. ACS Appl Mater Interfaces, 2025, 17(7): 10231-10245.
[50]
Jing B, Wan W, Hu B, et al. Plastic nanoparticles cause proteome stress and aggregation by compromising cellular protein homeostasis ex vivo and in vivo[J/OL]. Ecotoxicol Environ Saf, 2023, 262: 115347. DOI: 10.1016/j.ecoenv.2023.115347.
[51]
Jin Q, Chen D, Song Y, et al. Ultrasound-responsive biomimetic superhydrophobic drug-loaded mesoporous silica nanoparticles for treating prostate tumor[J/OL]. Pharmaceutics, 2023, 15(4): 1155. DOI: 10.3390/pharmaceutics15041155.
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