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中华关节外科杂志(电子版) ›› 2022, Vol. 16 ›› Issue (05) : 586 -591. doi: 10.3877/cma.j.issn.1674-134X.2022.05.009

综述

细胞焦亡与类风湿性关节炎的相关研究进展
马尧1, 杨明义1, 许珂2, 郝博1, 许鹏2,()   
  1. 1. 710054 西安市红会医院骨坏死与关节重建科;716000 延安大学医学院
    2. 710054 西安市红会医院骨坏死与关节重建科
  • 收稿日期:2020-05-29 出版日期:2022-10-01
  • 通信作者: 许鹏
  • 基金资助:
    国家自然科学基金(81271948)

Research advances in correlation between pyroptosis and rheumatoid arthritis

Yao Ma1, Mingyi Yang1, Ke Xu2, Bo Hao1, Peng Xu2,()   

  1. 1. Department of Osteonecrosis and Joint Reconstruction, Xi′an Honghui Hospital, Xi’an 710054, China; Yan′an University, Yan’an 716000, China
    2. Department of Osteonecrosis and Joint Reconstruction, Xi′an Honghui Hospital, Xi’an 710054, China
  • Received:2020-05-29 Published:2022-10-01
  • Corresponding author: Peng Xu
引用本文:

马尧, 杨明义, 许珂, 郝博, 许鹏. 细胞焦亡与类风湿性关节炎的相关研究进展[J/OL]. 中华关节外科杂志(电子版), 2022, 16(05): 586-591.

Yao Ma, Mingyi Yang, Ke Xu, Bo Hao, Peng Xu. Research advances in correlation between pyroptosis and rheumatoid arthritis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2022, 16(05): 586-591.

细胞焦亡是一种新近发现并已被证实与炎症有关的程序性细胞死亡方式,其过程与多种疾病的发生存在密切联系。类风湿性关节炎(RA)作为一种常见的炎症性自身免疫性疾病,其发病机制尚不完全清楚。以往研究显示,细胞焦亡过程在RA发病中扮演着重要角色。本文拟通过对细胞焦亡过程中所涉及的重要通路及分子与RA间的联系进行综述,为阐明RA发病机制、改善其治疗及预后提供新的理论依据。

Pyroptosis is a newly discovered and confirmed the pattern of programmed cell death associated with inflammation, which is strongly associated with the development of a variety of diseases. As a common inflammatory autoimmune disease, the pathogenesis of rheumatoid arthritis (RA) has not been fully understood. Previous studies have shown that the process of pyroptosis plays an important role in the pathogenesis of RA. This review aimed to provide a new theoretical basis for elucidating the pathogenesis of RA, improving the treatment and prognosis by summarizing the important pathways involved in the process of pyroptosis and the studies between the molecules and RA.

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