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中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (05) : 526 -529. doi: 10.3877/cma.j.issn.1674-134X.2019.05.002

所属专题: 文献

临床论著

阿司匹林预防髋关节置换术后深静脉血栓形成
杨健胜1, 关万宁1, 邓自立1, 李朝福1, 吴焯鹏1,()   
  1. 1. 529300 开平市中心医院
  • 收稿日期:2019-06-13 出版日期:2019-10-01
  • 通信作者: 吴焯鹏

Prevention of deep venous thrombosis after hip arthroplasty with aspirin

Jiansheng Yang1, Wanning Guan1, Zili Deng1, Chaofu Li1, Zhuopeng Wu1,()   

  1. 1. Kaiping Central Hospital, Kaiping 529300, China
  • Received:2019-06-13 Published:2019-10-01
  • Corresponding author: Zhuopeng Wu
  • About author:
    Corresponding author: Wu Zhuopeng, Email:
引用本文:

杨健胜, 关万宁, 邓自立, 李朝福, 吴焯鹏. 阿司匹林预防髋关节置换术后深静脉血栓形成[J/OL]. 中华关节外科杂志(电子版), 2019, 13(05): 526-529.

Jiansheng Yang, Wanning Guan, Zili Deng, Chaofu Li, Zhuopeng Wu. Prevention of deep venous thrombosis after hip arthroplasty with aspirin[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(05): 526-529.

目的

评价阿司匹林用于髋关节置换术后深静脉血栓预防的疗效与安全性。

方法

前瞻性纳入60岁以上髋关节置换术患者,排除凝血异常者,共124例,对研究者设盲,按抗凝药物不同以随机数字表分为4组,分别为对照组、阿司匹林组、序贯治疗组、联合治疗组,每组31例,比较术后5周深静脉血栓、出血事件发生率,比较各组药物费用。计量资料比较采用单因素方差分析,计数资料采用卡方检验。

结果

术后5周总深静脉血栓发生率为3.2%,各组间深静脉血栓发生率相当,差异没有统计学意义(χ2=2.067,P>0.05),各组未发生严重出血事件,阿司匹林组抗凝药物费用显著低于其他3组(t=16.472,P<0.001)。

结论

阿司匹林单独用于髋关节置换术后深静脉血栓预防安全有效。

Objective

To evaluate the efficacy and safety of aspirin as a prophylaxis agent against venous thromboembolism following hip arthroplasty.

Methods

According to inclusion (older than 60 years) and exclusion criteria (blood coagulation disurbance), 124 cases of hip arthroplasty were recruited prospectively and divided into four groups by random number table as control group, aspirin group, sequential therapy group and combined therapy group. Each group contained 31 cases. The rates of deep venous thrombosis, bleeding risk and fee of antithrombotic agent were compared among groups five weeks postoperatively. Analysis of variance (ANOVA) was used to measurement data, and chi-square test was used to enumeration data.

Results

The total rate of deep venous thrombosis was 3.2% and there wase no significant difference among four groups and between each two groups (χ2=2.067, P>0.05). No serious bleeding affair happened. The cost of antithrombotic agent of the aspirin group was significantly lower than other groups(t=16.472, P<0.01).

Conclusion

Aspirin is effective and safe enough to prevent deep venous thrombosis following hip arthroplasty.

表1 各组一般资料
表2 各组发生静脉血栓例数(例)
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