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中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 200 -205. doi: 10.3877/cma.j.issn.1674-134X.2019.02.012

所属专题: 文献

综述

白细胞介素-37与骨关节炎性疾病的研究进展
杨智坚1, 李奇1,()   
  1. 1. 510282 广州,南方医科大学珠江医院骨科中心
  • 收稿日期:2018-10-24 出版日期:2019-04-01
  • 通信作者: 李奇

Research progress of interleukin-37 in inflammatory diseases of bone and joint

Zhijian Yang1, Qi Li1,()   

  1. 1. Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
  • Received:2018-10-24 Published:2019-04-01
  • Corresponding author: Qi Li
  • About author:
    Corresponding author: Li Qi, Email:
引用本文:

杨智坚, 李奇. 白细胞介素-37与骨关节炎性疾病的研究进展[J]. 中华关节外科杂志(电子版), 2019, 13(02): 200-205.

Zhijian Yang, Qi Li. Research progress of interleukin-37 in inflammatory diseases of bone and joint[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(02): 200-205.

白细胞介素(IL)-37是近年发现的具有抑制炎症作用的IL-1家族细胞因子,共有a~e五种不同的亚型,其中IL-37b是目前研究的热点。最近研究发现,IL-37在骨关节炎性疾病的发生发展中对炎性因子和炎性介质的调节起着重要作用,但其具体调节机制尚不完全清楚。本文主要综述IL-37的生物学特征、信号通路及其在骨关节炎性疾病的研究现况,旨在为骨关节炎性疾病的发病机制、分型和诊断积累理论基础,为IL-37在骨关节炎性疾病的诊疗应用提供新思路。

Interleukin-37, known as one of IL-1 family members, was a recently found with broadly function in reducing innate inflammation as well as acquired immune responses. There are five variants in its transcripts (IL-37a-e), by which IL-37b is the focus of the studies. Important effect of IL-37 is found in the development of Inflammatory diseases of bone and joint. However, how it regulates in innate inflammation and acquired immune responses is not completely understood. To sum up theoretical basis for the pathogenesis, classification and diagnosis of inflammatory diseases of bone and joint and to provide new ideas for the application of IL-37 in the diagnosis and treatment of inflammatory diseases of bone and joint, this article reviewed the biological characteristics and signaling pathways of IL-37 and summary its researches in inflammatory diseases of bone and joint.

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