骨关节炎(OA)是运动系统中一种常见疾病，在世界范围内都有着较高的致残率。OA病程较长，在其演变过程中发生了一系列的病理生理改变，包括关节软骨的退化、新骨的形成以及滑膜增生等，疼痛是患者最常见的症状，随着疾病的发展，病变关节的功能逐渐减退，最终导致患者残疾。早期OA引起的损伤是可逆的，但缺乏早期诊断方法以及有效的治疗手段，患者往往都要经历疾病的终末阶段，关节置换是晚期OA患者治疗的唯一有效手段。因此探寻早期OA的诊断手段进而进行早期有效的针对性干预对于改善患者的预后有着重要的临床意义。近年来，蛋白组学在OA中的研究取得了一定的进展，尤其在OA生物学标志物方面；但是，如何将这些研究成果应用于临床有待于进一步研究，本文就蛋白组学在OA中的研究进展作一简要综述。

Osteoarthritis (OA) is a common disease in the motor system and has a high rate of disability worldwide.Due to the long course of OA disease, a series of pathological and physiological changes have occurred during its evolution, including the degeneration of articular cartilage, the formation of new bone and synovial hyperplasia, etc. Pain is the most common symptom of patients. With the development of the disease, the function of the diseased joints gradually decreases, and eventually leads to the disability of patients. The injury caused by early OA is reversible, but without early diagnosis and effective treatment, patients often go through the end stage of the disease. Joint replacement is the only effective treatment for patients with advanced OA.Therefore, it is of great clinical significance to explore the diagnostic means of early OA and carry out early effective targeted intervention to improve the prognosis of patients.In recent years, the study of proteomics in OA has made some progress, especially in the aspect of biological markers of OA. However, how to apply these results to clinical research remains to be further studied. This paper briefly reviewed the research progress of proteomics in OA.