Research progress of Raman spectroscopy in monitoring knee osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2023.02.018

Abstract

Abstract:

Raman spectroscopy is ever more applied in the research of knee arthritis, due to its significant advantages in identifications at molecular level and the potential applications in minimally invasive or even non-invasive diagnosis. With Raman spectroscopy, microscopic changes in articular cartilage, joint fluid and synovial tissue, etc. are identified for early diagnosis and treatment of knee arthritis. This paper intended to provide new theoretical basis for early diagnosis and treatment of osteoarthritis by reviewing the applications of Raman spectroscopy in detection and diagnosis of osteoarthritis.

Key words: Osteoarthritis, knee, Spectrum analysis, Raman, Cartilage, Synovial fluid

Yiran Zhu, Jian Qin. Research progress of Raman spectroscopy in monitoring knee osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(02): 276-282.

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References 47

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波数(cm^-1) Raman shift	结构归属Structural attribution	成分Composition
785	核酸	AC
816	C-C拉伸，蛋白质骨架	AC
856	C-C脯氨酸	AC，SB
875	C-C羟脯氨酸	AC，SB
898	β键C₁-H	SF透明质酸HA
941	C-C拉伸，胶原，α-螺旋	SF，AC
958	PO₄^3-对称收缩运动	CB
1 004	苯(基)丙氨酸	SF，AC，CB
1 060	反映有机基质的酰胺Ⅲ带	AC
1 063	SO₃^-糖胺聚糖中硫酸盐对称拉伸	AC，SF
1 070	CO₃^2-拉伸	CB
1 126	吡喃糖环	AC
1 235	酰胺III，β-折叠蛋白	SF，AC，CB
1 245	NH₂折叠，酰胺III，透明质酸	AC，SB
1 260	酰胺III，α-螺旋蛋白	AC，SB
1 301	脂质中CH₂变形	AC，SB
1 370	COO对称拉伸	SF透明质酸HA
1 375	PG振动	AC，SB
1 375	CH₃糖胺聚糖	AC
1 424	COO，葡糖氨基葡聚糖	AC
1 557	酰胺II	AC
1 640	酰胺I，次生胶原蛋白	AC
1 655	酰胺I，α-螺旋蛋白	SF
1 670	酰胺I，β-折叠蛋白	SF，AC
1 744	C＝O拉伸，脂质	AC，SB

波数(cm^-1) Raman shift	结构归属Structural attribution	成分Composition
785	核酸	AC
816	C-C拉伸，蛋白质骨架	AC
856	C-C脯氨酸	AC，SB
875	C-C羟脯氨酸	AC，SB
898	β键C₁-H	SF透明质酸HA
941	C-C拉伸，胶原，α-螺旋	SF，AC
958	PO₄^3-对称收缩运动	CB
1 004	苯(基)丙氨酸	SF，AC，CB
1 060	反映有机基质的酰胺Ⅲ带	AC
1 063	SO₃^-糖胺聚糖中硫酸盐对称拉伸	AC，SF
1 070	CO₃^2-拉伸	CB
1 126	吡喃糖环	AC
1 235	酰胺III，β-折叠蛋白	SF，AC，CB
1 245	NH₂折叠，酰胺III，透明质酸	AC，SB
1 260	酰胺III，α-螺旋蛋白	AC，SB
1 301	脂质中CH₂变形	AC，SB
1 370	COO对称拉伸	SF透明质酸HA
1 375	PG振动	AC，SB
1 375	CH₃糖胺聚糖	AC
1 424	COO，葡糖氨基葡聚糖	AC
1 557	酰胺II	AC
1 640	酰胺I，次生胶原蛋白	AC
1 655	酰胺I，α-螺旋蛋白	SF
1 670	酰胺I，β-折叠蛋白	SF，AC
1 744	C＝O拉伸，脂质	AC，SB

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