Research progress of magnesium in treatment of osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2023.03.009

Abstract

Abstract:

Magnesium is an important ion in the human body and participates in many physiological processes in the human body, including the synthesis of enzymes, the synthesis of bones, the synthesis of important neurotransmitters, and angiogenesis. Magnesium ions have a long history of use as clinical therapeutic agents, with a proven track record of analgesic and antispasmodic effects. There has not been much correlation between magnesium and the treatment of osteoarthritis. However, in recent studies, it has been found that magnesium is more and more related to the pathogenesis of osteoarthritis (OA) and its treatment. There are few reviews on this aspect, so this article is based on the latest research at home and abroad, focusing on the role of magnesium in the treatment of osteoarthritis to delay the degenerative changes of osteoarthritis, control inflammatory factors and related cells, reduce pain in patients with osteoarthritis, and the role of advanced joint replacement, as well as the relevant mechanisms in this. Determining the role of magnesium in the treatment of osteoarthritis can not only advance the understanding of the pathogenesis of osteoarthritis, but may ultimately serve as a new direction and new idea for the treatment of osteoarthritis in the future.

Key words: Magnesium, Osteoarthritis, cartilage, Mesenchymal stem cells, Inflammation

Zhuoyi Fu, Shengcheng Tang, Qiaomei Bu, Gaobing Xu, Anping Wu, Wei Cai, Ming Yang, Haitao Tan. Research progress of magnesium in treatment of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(03): 354-362.

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