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中华关节外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 44 -51. doi: 10.3877/cma.j.issn.1674-134X.2023.01.006

综述

间充质干细胞外泌体促进软骨再生的潜在机制研究
姜博庸1, 韩长旭2,()   
  1. 1. 010030 呼和浩特,内蒙古医科大学第二附属医院小儿骨科
    2. 010030 呼和浩特,内蒙古医科大学第二附属医院运动医学外科
  • 收稿日期:2021-10-20 出版日期:2023-02-01
  • 通信作者: 韩长旭
  • 基金资助:
    内蒙古自治区自然基金资助项目(2017MS0851,2017MS0815)

Potential mechanism of mesenchymal stem cell exosomes promoting cartilage regeneration

Boyong Jiang1, Changxu Han2,()   

  1. 1. Department of Pediatric Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
    2. Department of Sports Medicine, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
  • Received:2021-10-20 Published:2023-02-01
  • Corresponding author: Changxu Han
引用本文:

姜博庸, 韩长旭. 间充质干细胞外泌体促进软骨再生的潜在机制研究[J/OL]. 中华关节外科杂志(电子版), 2023, 17(01): 44-51.

Boyong Jiang, Changxu Han. Potential mechanism of mesenchymal stem cell exosomes promoting cartilage regeneration[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(01): 44-51.

在目前的动物学研究和临床医学研究中已经得以证实,间充质干细胞(MSC)在软骨损伤后修复的过程中具有一定程度的有效性。研究人员过去普遍认为MSC的治疗功效主要是源于其所具备的特有软骨分化潜能,而现如今的大量研究认为其治疗的功效主要来源于其旁分泌过程,特别是外泌体在其中的参与具有十分重要的作用。本文探究MSC的外泌体在通过免疫调节与激发再生潜能的方式修复软骨损伤过程中的可能机制。

Current animal and clinical studies have demonstrated the effectiveness of mesenchymal stem cells (MSC) in repairing cartilage damage. Previous researchers believe that the therapeutic effect of MSC is mainly based on the chondrogenic differentiation potential of MSC. Now more and more studies have attributed the therapeutic effect to paracrine, especially the role of exosomes. This review aimed to investigate the potential mechanism of mesenchymal stem cell (MSC) exosomes in repair of cartilage damage through immune regulation and regeneration potential.

表1 MSCs在软骨修复和再生中的作用相关研究汇总表
表2 MSCs外泌体相关研究进展汇总表
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