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中华关节外科杂志(电子版) ›› 2018, Vol. 12 ›› Issue (04) : 539 -543. doi: 10.3877/cma.j.issn.1674-134X.2018.04.016

所属专题: 文献

综述

α-2巨球蛋白在急性创伤性骨关节炎及相关疾病中的研究进展
赵瑞鹏1, 王少伟1, 李鹏翠1, 李刚1, 王春理1, 赵昱1, 张志伟1, 卫小春1,()   
  1. 1. 030001 太原,山西医科大学第二临床医学院骨与软组织损伤修复山西省重点实验室
  • 收稿日期:2016-05-08 出版日期:2018-08-01
  • 通信作者: 卫小春
  • 基金资助:
    国家国际科技合作专项项目(2015DFA33050); 国家自然科学基金(81201435)

Research progression of alpha-2-macroglobulin in post-traumatic osteoarthritis and relataed diseases

Ruipeng Zhao1, Shaowei Wang1, Pengcui Li1, Gang Li1, Chunli Wang1, Yu Zhao1, Zhiwei Zhang1, Xiaochun Wei1,()   

  1. 1. Shanxi Key laboratory of Bone and Soft Tissue Injury Repair, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2016-05-08 Published:2018-08-01
  • Corresponding author: Xiaochun Wei
  • About author:
    Corresponding author: Wei Xiaochun, Email:
引用本文:

赵瑞鹏, 王少伟, 李鹏翠, 李刚, 王春理, 赵昱, 张志伟, 卫小春. α-2巨球蛋白在急性创伤性骨关节炎及相关疾病中的研究进展[J]. 中华关节外科杂志(电子版), 2018, 12(04): 539-543.

Ruipeng Zhao, Shaowei Wang, Pengcui Li, Gang Li, Chunli Wang, Yu Zhao, Zhiwei Zhang, Xiaochun Wei. Research progression of alpha-2-macroglobulin in post-traumatic osteoarthritis and relataed diseases[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(04): 539-543.

随着社会的快速发展,创伤性骨关节炎患者越来越多,给患者及社会带来沉重的负担。随着研究的不断深入,具有广谱蛋白酶抑制作用的α-2巨球蛋白(α2M)在创伤性骨关节炎及相关疾病的保护作用不断被发现。本文就此作一综述,详细阐述了α2M的功能,结构;α2M在创伤性骨关节炎中的早期诊断、保护作用;在膝关节交叉韧带损伤修复中的促进作用;在半月板损伤中的保护作用;在韧带重建中骨-腱愈合的促进作用。最后,本文指出了目前面临的一些挑战,如,α2M的具体作用机制,生物安全性需要进一步深入研究。

The growing population of post-traumatic osteoarthritis(PTOA) patients have brought great burden to both the patients themselves and the society. However, with the discover of alpha-2-macroglobulin(α2M), a broad spectrum of protease inhibitors, the greater protective effect has been found on post-traumatic osteoarthritis and relataed diseases. This article reviewed the structure and fuction of α2M, the main effect on early diagnosis and treatment of PTOA, the promotion during the repair of anterior cruciate ligament injury, the protective effects on meniscus injury and the positive effects on tendon-bone healing during anadesma reconstruction. This article also pointed out some of the major challenges including specific mechanisms of action and biosecurity of α2M, which need some in-depth studies in the future.

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