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中华关节外科杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 462 -466. doi: 10.3877/cma.j.issn.1674-134X.2022.04.012

综述

富血小板血浆在股骨头坏死治疗中的研究进展
余少君1, 汪衍雪1, 栾烁1, 马超1, 伍少玲1,()   
  1. 1. 510000 广州,中山大学孙逸仙纪念医院康复科
  • 收稿日期:2020-06-01 出版日期:2022-08-01
  • 通信作者: 伍少玲
  • 基金资助:
    中山大学孙逸仙纪念医院逸仙临床研究项目(SYS-C-201704;SYS-C-202002)

Advances in platelet-rich plasma in treatment of femoral head osteonecrosis

Shaojun Yu1, Yanxue Wang1, Shuo Luan1, Chao Ma1, Shaoling Wu1,()   

  1. 1. Department of Rehabilitation Medicine, sun yat-sen memorial hospital, sun yat-sen university, Guangzhou 510000, China
  • Received:2020-06-01 Published:2022-08-01
  • Corresponding author: Shaoling Wu
引用本文:

余少君, 汪衍雪, 栾烁, 马超, 伍少玲. 富血小板血浆在股骨头坏死治疗中的研究进展[J/OL]. 中华关节外科杂志(电子版), 2022, 16(04): 462-466.

Shaojun Yu, Yanxue Wang, Shuo Luan, Chao Ma, Shaoling Wu. Advances in platelet-rich plasma in treatment of femoral head osteonecrosis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2022, 16(04): 462-466.

富血小板血浆(PRP)是一种自体外周血经梯度密度离心后获得的高度浓缩血小板。由于PRP自体来源,制作简易,且安全有效,近几年在临床上的应用日益广泛,目前临床应用范围已涉及骨科、口腔科、疼痛科、内分泌科等多个专科。其中已有大量高质量研究表明PRP可用于治疗肱骨外上髁炎和膝关节骨关节炎。虽然PRP在临床应用的范围及有效性仍存在争议,但其在股骨头坏死中的应用越来越受到关注。无论是单纯PRP髋关节腔注射,还是与多种生物组份联合运用,疗效均受到了一定肯定。本文就PRP在股骨头坏死治疗中的研究进展作一综述。

Platelet-rich plasma (PRP) is a kind of highly concentrated platelets obtained by centrifugation of autologous peripheral blood by gradient density. In recent years, due to self-source, easy to make, safe and effective, PRP has been widely used in clinical practice. At present, it has been applied in orthopedics, stomatology, pain clinic, endocrinology etc. Abundant high-quality evidence supports the use of PRP injection for lateral epicondylitis and osteoarthritis of the knee.Although the range and validity of PRP in clinical application is still controversial, more and more attention is paid to its application in osteonecrosis of the femoral head(ONFH). Not only PRP alone but also combined with biomaterials, the curative effect has been partly affirmed. This article reviewed the research progress about PRP applied in the treatment of ONFH.

图1 中山大学孙逸仙纪念医院康复科PRP(富血小板血浆)制备简单流程
图2 PRP(富血小板血浆)治疗股骨头坏死可能作用机制
[1]
Zhou W, Qu M, Lv Y, et al. New advances in stem cell therapy for osteonecrosis of the femoral head[J]. Curr Stem Cell Res Ther, 2019, 14(3): 226-229.
[2]
中国医师协会骨科医师分会显微修复工作委员会,中国修复重建外科专业委员会骨缺损及骨坏死学组,中华医学会骨科分会显微修复学组.成人股骨头坏死临床诊疗指南(2016)[J].中华骨科杂志201636(15):945-954.
[3]
Thompson GH, Lea ES, Chin K, et al. Closed bone graft epiphysiodesis for avascular necrosis of the capital femoral epiphysis[J]. Clin Orthop Relat Res, 2013, 471(7): 2199-2205.
[4]
Ehlinger M, Moser T, Adam P, et al. Early prediction of femoral head avascular necrosis following neck fracture[J]. Orthop Traumatol Surg Res, 2011, 97(1): 79-88.
[5]
Bartoníček J, Vávra J, Bartoška R, et al. Operative treatment of avascular necrosis of the femoral head after proximal femur fractures in adolescents[J]. Int Orthop, 2012, 36(1): 149-157.
[6]
Zhang Y, Yin J, Ding H, et al. Vitamin K2 ameliorates damage of blood vessels by glucocorticoid: a potential mechanism for its protective effects in glucocorticoid-induced osteonecrosis of the femoral head in a rat model[J]. Int J Biol Sci, 2016, 12(7): 776-785.
[7]
Wessel JH, Dodson TB, Zavras AI. Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study[J]. J Oral Maxillofac Surg, 2008, 66(4): 625-631.
[8]
Dodson TB, Zavras AI. Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids:a multicenter casecontrol study in Japan[J]. J Orthop Sci, 2012, 17(6): 730-736.
[9]
Liu BY, Zhao DW, Yu XB, et al. Effect of superior retinacular artery damage on osteonecrosis of the femoral head[J]. Chin Med J (Engl), 2013, 126(20): 3845-3850.
[10]
Feng Y, Yang SH, Xiao BJ, et al. Decreased in the number and function of circulation endothelial progenitor cells in patients with avascular necrosis of the femoral head[J]. Bone, 2010, 46(1): 32-40.
[11]
Mukisi M, Bashoun K, Burny F. Sickle-cell hip necrosis and intraosseous pressure[J]. Orthop Traumatol Surg Res, 2009, 95(2):134-138.
[12]
Zhang H, Zhou F, Pan Z, et al. 11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids[J]. Biochem Biophys Res Commun, 2017, 490(4): 1399-1406.
[13]
Arnoczky SP, Shebani-Rad S. The basic science of platelet-rich plasma (PRP): what clinicians need to know[J]. Sports Med Arthrosc, 2013, 21(4): 180-185.
[14]
Hood A, Hill AG, Reeder GD, et al. Peri-operative autologous sequestration III: a new physilolgic glue with wound healing properties[J]. Proc Am Acad Cardiovasc Perfusion, 1993, 14(126): 126-129.
[15]
袁霆,张长青.骨组织及软组织修复作用中富血小板血浆的制作及其原理[J].中国临床康复20048(35):7939-7941.
[16]
Anitua E. Plasma rich in growth factors:preliminary results of use in the preparation of future sites for implants[J]. Int J Oral Maxillofac Implants, 1999, 14(4): 529-535.
[17]
Landesberg R, Roy M, Glickman RS. Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation[J]. J Oral Maxillofac Surg, 2000, 58(3): 297-300; discussion 300-301.
[18]
Aghaloo TL, Peter KM, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study[J]. J Oral Maxillofac Surg, 2002, 60(10): 1176-1181.
[19]
Mei DO, Laver L, Nyska M, et al. Platelet rich plasma--a new biotechnology for treatment of sports injuries[J]. Harefuah, 2011, 150(5): 453-457, 490.
[20]
Modarressi A. Platlet rich plasma(PRP)improves fat grafting outcomes[J]. World J Plast Surg, 2013, 2(1): 6-13.
[21]
Lang S, Loibl M, Herrmann M. Platelet-rich plasma in tissue engineering: hype and hope[J]. Eur Surg Res, 2018, 59(3/4): 265-275.
[22]
Mussano F, Genova T, Munaron L, et al. Cytokine, chemokine, and growth factor profile of platelet-rich plasma[J]. Platelets, 2016, 27(5): 467-471.
[23]
Sánchez M, Anitua E, Delgado D, et al. Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration[J]. Expert Opin Biol Ther, 2017, 17(2): 197-212.
[24]
Osterman C, Mccarthy MB, Cote MP,et al. Platelet-rich plasma increases anti-inflammatory markers in a human coculture model for osteoarthritis[J]. Am J Sports Med, 2015, 43(6): 1474-1484.
[25]
Zhang XL, Shi KQ, Jia PT, et al. Effects of platelet-rich plasma on angiogenesis and osteogenesis-associated factors in rabbits with avascular necrosis of the femoral head[J]. Eur Rev Med Pharmacol Sci, 2018, 22(7): 2143-2152.
[26]
Zhang XL, Wang YM, Chu K, et al. The application of PRP combined with TCP in repairing avascular necrosis of the femoral head after femoral neck fracture in rabbit[J]. Eur Rev Med Pharmacol Sci, 2018, 22(4): 903-909.
[27]
胡钟旭,李东卿,李贵涛,等.富血小板血浆联合骨髓间充质干细胞治疗家兔股骨头缺血坏死的研究[J/CD].中华损伤与修复杂志(电子版)20149(1):22-26.
[28]
周斌,廖琦,程立明,等.富血小板血浆对股骨头坏死微环境下犬骨髓基质干细胞增殖与分化的影响[J].中华创伤骨科杂志201315(11):994-998.
[29]
Pak J, Lee JH, Jeon JH, et al. Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma[J]. J Int Med Res, 2014, 42(6): 1353-1362.
[30]
Martin JR, Houdek MT, Sierra RJ. Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis[J]. Croat Med J, 2013, 54(3): 219-224.
[31]
Guadilla J, Fiz N, Andia I, et al. Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip[J]. Knee Surg Sports Traumatol Arthrosc, 2012, 20(2): 393-398.
[32]
Ibrahim V, Dowling H. Platelet-rich plasma as a nonsurgical treatment option for osteonecrosis[J]. PMR, 2012, 4(12): 1015-1019.
[33]
Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 85(6): 638-646.
[34]
Bottegoni C, Dei Giudici L, Salvemini S, et al. Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study[J]. Ther Adv MusculoskeletDis, 2016, 8(2): 35-41.
[35]
Razaq S, Ejaz A, Rao S, et al. The role of intraarticular platelet rich plasma (PRP) injection in patients with internal knee derangements[J]. J Coll Physicians Surg Pak, 2015, 25(9): 699-701.
[36]
栾烁,阮玉婷,栗晓,等.富血小板血浆修复重建退变腰椎间盘组织的基础与临床研究进展[J].解剖学研究201739(6):487-490.
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