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中华关节外科杂志(电子版) ›› 2018, Vol. 12 ›› Issue (04) : 551 -560. doi: 10.3877/cma.j.issn.1674-134X.2018.04.018

所属专题： 文献；

综述

富血小板血浆治疗肌腱病的疗效分析
韩亚光1, 周义钦1, 钱齐荣1,†()   
  1. 1. 200003　上海，第二军医大学长征医院关节外科
  • 收稿日期:2018-03-07 出版日期:2018-08-01
  • 通信作者: 钱齐荣
  • 基金资助:
    国家自然科学基金(81702209)

Analysis of platelet-rich plasma treatment efficacy for tendinopathy: from basic research to clinical study

Yaguang Han1, Yiqin Zhou1, Qirong Qian1,†()   

  1. 1. Department of Joint Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Received:2018-03-07 Published:2018-08-01
  • Corresponding author: Qirong Qian
  • About author:
    Corresponding author: Qian Qirong, Email:
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韩亚光, 周义钦, 钱齐荣. 富血小板血浆治疗肌腱病的疗效分析[J]. 中华关节外科杂志(电子版), 2018, 12(04): 551-560.

Yaguang Han, Yiqin Zhou, Qirong Qian. Analysis of platelet-rich plasma treatment efficacy for tendinopathy: from basic research to clinical study[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(04): 551-560.

富血小板血浆(PRP)已被广泛应用于骨科和运动医学等领域来治疗肌腱病。然而临床运用PRP治疗肌腱病疗效究竟如何仍具有争议。本文回顾了近年来所报道的基于良好控制条件下所进行的关于PRP的基础科学研究，并联系临床试验结果，进行对比和讨论。事实上，无论是体内研究还是体外研究，都描述了PRP对肌腱具有促进合成代谢和抗炎作用。虽然一些临床试验支持这些发现，但也有一部分试验否认这些观点。本篇综述将基于基础研究呈现的证据来讨论PRP治疗肌腱损伤的有效性，同时探讨部分临床试验结果出现争议的潜在原因。最后，文章总结了用于改善PRP对肌腱病疗效的方法。

关键词: 富血小板血浆, 肌腱病, 腱损伤, 白细胞, 血小板, 胞间信号肽和蛋白质类

Platelet-rich plasma (PRP) is a quickly progressing therapeutic option to treat tendon injuries in sports medicine and orthopaedic surgery. However, the efficacy of PRP in curing tendinopathy is still in dispute. This paper reviewed the basic science research published in recent years conducted under well-controlled conditions and linked it with clinical trial results to make comparison and discussion. In fact, both in vivo and in vitro studies have described that PRP has anabolic and anti-inflammatory effects on tendons. While a number of clinical trials support the above-mentioned findings, others refute them. This review discussed the effectiveness of PRP in curing tendon injuries based on evidence presented from basic science research and the potential reasons for the controversial results in some clinical trials. In the end, it also summarized the approaches which can improve the efficacy of PRP treatment for tendinopathy.

Key words: Platelet-rich plasma, Tendinopathy, Tendon injuries, Leukocytes, Blood platelets, Intercellular signaling peptides and proteins
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