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中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (06) : 773 -777. doi: 10.3877/ cma.j.issn.1674-134X.2024.06.011

综述

富血小板血浆治疗早期股骨头坏死的研究进展
王静1, 赵乐1, 曾健康1, 李培杰1, 谭飞1, 李嘉欢1, 乔永杰2, 周胜虎2,()   
  1. 1.730030 兰州,甘肃中医药大学
    2.730050 兰州解放军联勤保障部队第九四〇医院
  • 收稿日期:2024-06-04 出版日期:2024-12-01
  • 通信作者: 周胜虎
  • 基金资助:
    甘肃省重点研发计划(21YF5FA154)甘肃省青年科技基金(20JR5RA588)

Research progress on treatment of early femoral head necrosis with platelet rich plasma

Jing Wang1, Le Zhao1, Jiankang Zeng1, Peijie Li1, Fei Tan1, Jiahuan Li1, Yongjie Qiao2, Shenghu Zhou2,()   

  1. 1.Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
    2.940 Hospital of the Joint Logistics Support Force of PLA,Lanzhou 730050, China
  • Received:2024-06-04 Published:2024-12-01
  • Corresponding author: Shenghu Zhou
引用本文:

王静, 赵乐, 曾健康, 李培杰, 谭飞, 李嘉欢, 乔永杰, 周胜虎. 富血小板血浆治疗早期股骨头坏死的研究进展[J/OL]. 中华关节外科杂志(电子版), 2024, 18(06): 773-777.

Jing Wang, Le Zhao, Jiankang Zeng, Peijie Li, Fei Tan, Jiahuan Li, Yongjie Qiao, Shenghu Zhou. Research progress on treatment of early femoral head necrosis with platelet rich plasma[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(06): 773-777.

股骨头坏死是骨科常见且治疗困难的髋关节疾病,主要临床表现为跛行、髋关节屈伸活动受限及髋部疼痛。如不及时治疗一旦引起股骨头塌陷或继发骨关节炎,最终需行全髋关节置换术。目前临床上治疗股骨头坏死主要根据国际骨循环学会(ARCO)分期选择不同的治疗方式。针对早期患者通常采取“保髋”治疗,常用术式有髓心减压、自体骨移植、干细胞治疗等;而对于晚期患者则多采取全髋关节置换术。但是,防治塌陷一直是治疗股骨头坏死的关键节点。近年来,富血小板血浆(PRP)在促进股骨头软骨修复及血管再生等方面具有较好效果。因此,本文对PRP治疗股骨头坏死的机制及其临床应用进行归纳整理,以期对后续研究提供参考和方向。

Necrosis of the femoral head is a common and difficult-to-treat hip disease in orthopedics,with the main clinical manifestations of claudication, limitation of hip flexion and extension activities, and hip pain. If left untreated once the femoral head collapses or secondary osteoarthritis occurs, total hip replacement is eventually required. Currently, the clinical treatment of femoral head necrosis is mainly based on Association Research Circulation Osseous (ARCO) staging to choose different treatment modalities. Early-stage patients are usually treated with "hip preservation", and the commonly used surgical methods include medullary decompression, autologous bone grafting, stem cell therapy, etc., while total hip arthroplasty is often used for advanced patients. However, prevention of collapse has always been the key point in the treatment of femoral head necrosis. In recent years, platelet-rich plasma (PRP) has been effective in promoting cartilage repair and vascular regeneration of the femoral head. Therefore, this paper summarized the mechanism of PRP in the treatment of femoral head necrosis and its clinical application, with a view to providing reference and direction for subsequent research.

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