Hydrogel drug delivery systems in treatment of rheumatoid arthritis

doi:10.3877/cma.j.issn.1674-134X.2020.05.013

Abstract

Abstract:

Rheumatoid arthritis (RA) is a systemic disease which seriously harms the health of patients. An increasing number of drugs appears due to the development of treatment methods. However, disadvantages such as drug side effects and efficacy still exist, which are negative for the treatment and recovery of RA patients. At present, more and more new drug delivery systems have been discovered, which have excellent performance in improving targeting, utilization and sustained release of target drugs. Among them, the hydrogel drug delivery system has unique advantages compared with other drug delivery systems for its characteristics and structure, which has possible ability to improve the current treatment means. This article focused on the research progress of several hydrogel drug delivery systems in RA drug therapy.

Key words: Rheumatoid arthritis, Drug therapy, Review

Shunan Gu, Qi Li. Hydrogel drug delivery systems in treatment of rheumatoid arthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2020, 14(05): 597-601.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhgjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-134X.2020.05.013

https://zhgjwkzz.cma-cmc.com.cn/EN/Y2020/V14/I05/597

Figures/Tables 1

References 32

[1]	中华医学会风湿病学分会.2018中国类风湿关节炎诊疗指南[J]．中华内科杂志，2018，57(4)：242-251.
[2]	Sparks JA. Rheumatoid arthritis[J]. Ann Intern Med, 2019, 170(1): ITC1-ITC16.
[3]	Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis[J]. Lancet, 2017, 389(186): 2338-2348.
[4]	Mitragotri S, Yoo JW. Designing micro- and nano-particles for treating rheumatoid arthritis[J]. Arch Pharm Res, 2011, 34(11): 1887-1897.
[5]	Prasad LK, O'mary H, Cui ZR. Nanomedicine delivers promising treatments for rheumatoid arthritis[J]. Nanomedicine (Lond), 2015, 10(13): 2063-2074.
[6]	Raza F, Zafar H, Zhu Y, et al. A review on recent advances in stabilizing peptides/proteins upon fabrication in hydrogels from biodegradable polymers[J/OL]. Pharmaceutics, 2018, 10(1): 16. doi: 10.3390/pharmaceutics10010016.
[7]	Kalpana RK, Kinam P. Biodegradable hydrogels in drug delivery[J]. Adv Drug Deliv Rev, 1993, 11(1/2): 59-84.
[8]	Yu Z, Xu Q, Dong C, et al. Self-Assembling peptide nanofibrous hydrogel as a versatile drug delivery platform[J]. Curr Pharm Des, 2015, 21(29): 4342-4354.
[9]	Wichterle O, Lím D. Hydrophilic Gels for biological use[J]. Nature, 1960, 185(476): 117-118.
[10]	Xu X, Weng Y, Xu L, et al. Sustained release of Avastin? from polysaccharides cross-linked hydrogels for ocular drug delivery[J]. Int J Biol Macromol, 2013, 60: 272-276.
[11]	Wan JM, Liu LL, Zhang JF, et al. Promotion of neuronal regeneration by using self-polymerized dendritic polypeptide scaffold for spinal cord tissue engineering[J/OL]. J Mater Sci Mater Med, 2017, 29(1): 6. doi: 10.1007/s10856-017-6010-8.
[12]	Liu JF, Liu JJ, Chu L, et al. Self-assembling peptide of D-amino acids boosts selectivity and antitumor efficacy of 10-hydroxycamptothecin[J]. ACS Appl Mater Interfaces, 2014, 6(8): 5558-5565.
[13]	Lock LL, Cheetham AG, Zhang P, et al. Design and construction of supramolecular nanobeacons for enzyme detection[J]. ACS Nano, 2013, 7(6): 4924-4932.
[14]	Appel EA, Del Barrio J, Loh XJ, et al. Supramolecular polymeric hydrogels[J]. Chem Soc Rev, 2012, 41(18): 6195-6214.
[15]	Rybtchinski B. Adaptive supramolecular nanomaterials based on strong noncovalent interactions[J]. ACS Nano, 2011, 5(9): 6791-6818.
[16]	Ma Z, Tao C, Sun L, et al. In situ forming injectable hydrogel for encapsulation of nanoiguratimod and sustained release of therapeutics[J]. Int J Nanomedicine, 2019, 14: 8725-8738.
[17]	Yu X, Liu Q, Wu J, et al. Sonication-triggered instantaneous gel-to-gel transformation[J]. Chemistry, 2010, 16(30): 9099-9106.
[18]	Tang C, Smith AM, Collins RF, et al. Fmoc-diphenylalanine self-assembly mechanism induces apparent pKa shifts[J]. Langmuir, 2009, 25(16): 9447-9453.
[19]	Yin N, Guo XE, Sun R, et al. Intra-articular injection of indomethacin-methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis[J]. J Mater Chem B, 2020, 8(5): 993-1007.
[20]	Pan W, Dai CB, Li Y, et al. PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis[J/OL]. Biomaterials, 2020, 239: 119851. doi: 10.1016/j.biomaterials.2020.119851.
[21]	Wu H, Wang KY, Wang HN, et al. Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy[J]. Colloids Surf B Biointerfaces, 2017, 149: 97-104.
[22]	Park J, Pramanick S, Park D, et al. Therapeutic-Gas-Responsive hydrogel[J/OL]. Adv Mater, 2017, 29(44). doi：10.1002/adma.201702859.
[23]	Yeo J, Lee YM, Lee J, et al. Nitric Oxide-Scavenging nanogel for treating rheumatoid arthritis[J]. Nano Lett, 2019, 19(10): 6716-6724.
[24]	Wang C, Javadi A, Ghaffari M, et al. A pH-sensitive molecularly imprinted nanospheres/hydrogel composite as a coating for implantable biosensors[J]. Biomaterials, 2010, 31(18): 4944-4951.
[25]	Liang L, Li J, Li Q, et al. Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells[J]. Angew Chem Int Ed Engl, 2014, 53(30): 7745-7750.
[26]	Du X, Zhou J, Shi JF, et al. Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials[J]. Chem Rev, 2015, 115(24): 13165-13307.
[27]	Estroff LA, Hamilton AD. Water gelation by small organic molecules[J]. Chem Rev, 2004, 104(3): 1201-1218.
[28]	Tian Y, Wang H, Liu Y, et al. A peptide-based nanofibrous hydrogel as a promising DNA nanovector for optimizing the efficacy of HIV vaccine[J]. Nano Lett, 2014, 14(3): 1439-1445.
[29]	Li J, Kuang Y, Gao Y, et al. D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID)[J]. J Am Chem Soc, 2013, 135(2): 542-545.
[30]	Chen Z, Xing L, Fan Q, et al. Drug-Bearing supramolecular filament hydrogels as anti-inflammatory agents[J]. Theranostics, 2017, 7(7): 2003-2014.
[31]	Kanazawa T, Tamano K, Sogabe K, et al. Intra-articular retention and anti-arthritic effects in collagen-induced arthritis model mice by injectable small interfering RNA containing hydrogel[J]. Biol Pharm Bull, 2017, 40(11): 1929-1933.
[32]	Liu H, Ding J, Li C, et al. Hydrogel is superior to fibrin gel as matrix of stem cells in alleviating antigen-induced arthritis[J/OL]. Polymers (Basel), 2016, 8(5): 182. doi：10.3390/polym8050182.

药物分类	药物名称	作用	不良反应
NSAIDs	阿司匹林等	减轻急性炎症	消化道出血可能性
DMARDs	甲氨蝶呤等	延缓疾病进展	肝硬化、骨髓抑制、视网膜病变、肝硬化等
糖皮质激素	地塞米松等	抗炎	感染风险、癌症风险等
生物制剂	英夫利昔单抗等	延缓疾病进展	感染风险

药物分类	药物名称	作用	不良反应
NSAIDs	阿司匹林等	减轻急性炎症	消化道出血可能性
DMARDs	甲氨蝶呤等	延缓疾病进展	肝硬化、骨髓抑制、视网膜病变、肝硬化等
糖皮质激素	地塞米松等	抗炎	感染风险、癌症风险等
生物制剂	英夫利昔单抗等	延缓疾病进展	感染风险

Please choose a citation manager

Content to export