Advances in impact of myeloid-derived suppressor cells on prosthetic joint infections

doi:10.3877/cma.j.issn.1674-134X.2020.05.012

Abstract

Abstract:

Prosthetic joint infection (PJI) is a serious complication after arthroplasty and staphylococcus aureus(S. aureus) is the most common pathogen of PJI. Biofilm formation allows S. aureus to resist attacks from antibiotics and the host's immune system, which Increases the difficulty of PJI treatment. Myeloid-derived suppressor cells can inhibit the host's immune response to Staphylococcus aureus and play an important role in maintaining the formation of S. aureus biofilms and causing chronic PJI. This review aimed to illustrate the effect of myeloid-derived suppressor cells on staphylococcal aureus induced prosthetic joint infections and advances achieved in this area.

Key words: Joint prosthesis, Infection, Staphylococcus aureus, Myeloid-derived suppressor cells

Feng Jiang, Jinlong Yu, Feiyang Zhang, Jiafei Du, Hao Shen. Advances in impact of myeloid-derived suppressor cells on prosthetic joint infections[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2020, 14(05): 592-596.

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