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中华关节外科杂志(电子版) ›› 2026, Vol. 20 ›› Issue (01) : 69 -76. doi: 10.3877/cma.j.issn.1674-134X.2026.01.009

综述

中性粒细胞在骨关节炎发病机制中的作用与机制
马天佑, 吴默, 赵雪飞, 吕帅洁, 童培建†()   
  1. 310000　杭州，浙江中医药大学第一临床医学院
  • 收稿日期:2025-04-16 出版日期:2026-02-01
  • 通信作者: 童培建
  • 基金资助:
    国家自然科学基金(82274547)

Roles and mechanisms of neutrophils in disease pathogenesis of osteoarthritis

Tianyou Ma, Mo Wu, Xuefei Zhao, Shuaijie Lyu, Peijian Tong†()   

  1. First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, China
  • Received:2025-04-16 Published:2026-02-01
  • Corresponding author: Peijian Tong
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马天佑, 吴默, 赵雪飞, 吕帅洁, 童培建. 中性粒细胞在骨关节炎发病机制中的作用与机制[J/OL]. 中华关节外科杂志(电子版), 2026, 20(01): 69-76.

Tianyou Ma, Mo Wu, Xuefei Zhao, Shuaijie Lyu, Peijian Tong. Roles and mechanisms of neutrophils in disease pathogenesis of osteoarthritis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2026, 20(01): 69-76.

骨关节炎是一种常见的关节疾病，其特征为软骨损伤和慢性炎症，严重影响患者的生活质量。近年来的研究表明，中性粒细胞作为重要的免疫细胞，在骨关节炎的发病机制中扮演着关键角色。中性粒细胞不仅在炎症反应中发挥作用，还可能对软骨的修复过程产生影响。然而，目前关于中性粒细胞在骨关节炎中作用的研究仍有待进一步深入。本文旨在综述中性粒细胞在骨关节炎中的作用及其相关机制，并评估了靶向中性粒细胞的治疗潜力，以期为未来的研究和治疗提供新的思路和方向。

关键词: 中性白细胞, 骨关节炎, 细胞微环境, 软骨疾病, 炎症

Osteoarthritis is a common joint disease characterized by cartilage damage and chronic inflammation, significantly affecting the quality of life of patients. Recent studies suggest that neutrophils, as important immune cells, play a critical role in the pathogenesis of osteoarthritis. Neutrophils are involved not only in inflammatory responses but may also influence the cartilage repair process. However, current research on the role of neutrophils in osteoarthritis still requires further investigation. This review aimed to summarize the role of neutrophils in osteoarthritis and its underlying mechanisms, and assess the therapeutic potential of targeting neutrophils, providing new insights and directions for future research and treatment.

Key words: Neutrophils, Osteoarthritis, Cellular microenvironment, Cartilage diseases, Inflammation
图1 中性粒细胞在OA（骨关节炎）发病机制中的作用示意图注：ROS-活性氧；DAMPs-损伤相关分子模式；NETS-中性粒细胞外陷阱
Figure 1 Schematic illustration of the role of neutrophils in the pathogenesis ofOA（osteoarthritis）Note: ROS-reactive oxygen rpecies; DAMPs-damage-associated molecular patterns; NETS-neutrophil extracellular traps
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[15] 周懿, 黄容华, 刘政疆. 5-羟色胺与铁死亡介导的脓毒症心肌病的研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(08): 612-617.
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