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中华关节外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (06) : 720 -727. doi: 10.3877/cma.j.issn.1674-134X.2025.06.011

综述

富血小板血浆注射治疗肩袖部分撕裂的研究进展
韦俊名1,2, 许德玮1,2, 林荣钊1,2, 彭亮权1,2,()   
  1. 1518035 深圳大学
    2518035 深圳市第二人民医院,深圳大学第一附属医院运动医学科
  • 收稿日期:2025-02-24 出版日期:2025-12-01
  • 通信作者: 彭亮权

Advances in research on platelet-rich plasma injection for partial-thickness rotator cuff tears

Junming Wei1,2, Dewei Xu1,2, Rongzhao Lin1,2, Liangquan Peng1,2,()   

  1. 1Shenzhen University, Shenzhen 518035, China
    2Sport Medicine of the Second People’s Hospital of Shenzhen, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China
  • Received:2025-02-24 Published:2025-12-01
  • Corresponding author: Liangquan Peng
引用本文:

韦俊名, 许德玮, 林荣钊, 彭亮权. 富血小板血浆注射治疗肩袖部分撕裂的研究进展[J/OL]. 中华关节外科杂志(电子版), 2025, 19(06): 720-727.

Junming Wei, Dewei Xu, Rongzhao Lin, Liangquan Peng. Advances in research on platelet-rich plasma injection for partial-thickness rotator cuff tears[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(06): 720-727.

肩袖撕裂是肩部常见的疾病,是导致肩关节功能障碍以及疼痛的主要原因之一。已有大型的流行病研究发现,肩袖撕裂在一般人群有较高的患病率。肩袖撕裂根据撕裂厚度分为全层撕裂和部分撕裂,肩袖部分撕裂(PTRCTs)是肩袖部分厚度的撕裂。目前对肩袖部分撕裂,关于最佳治疗方法还没有明确的共识,因为肩袖乏血供的解剖特点以及承受的机械应力,部分患者经保守治疗后,肩袖的自行修复仍十分困难,症状及功能难以改善,因此提出目前治疗的重点是探求更进一步的愈合可能。而富血小板血浆(PRP)注射治疗在再生修复方面具有极大的潜力,因此PRP逐渐成为PTRCTs的治疗方案之一。PRP是新鲜全血经离心后提取的血小板浓缩物,是目前较常用的生物制剂,临床上已广泛应用于各种组织的修复并取得了一定的效果,特别是肌腱疾病方面有一定的疗效。但PRP治疗PTRCTs的有效性、安全性及撕裂的类型都有待探究。本文通过对近年来PRP治疗PTRCTs的文献进行回顾,PRP相较于其他注射疗法在疼痛与功能改善上的优势;其安全性与特定不良事件风险;针对关节侧与滑囊侧、不同分级撕裂的疗效差异;以及与皮质类固醇等药物对比的长期获益与特点,分析PRP治疗PTRCTs的有效性、安全性、撕裂类型的适应证,为PRP的合理应用提供参考,同时也为PRP的临床应用提供新思路。

Rotator cuff tear is a common shoulder disease and one of the main causes of shoulder joint dysfunction and pain.Large epidemiological studies have identified a higher prevalence of rotator cuff tears in the general population.Rotator cuff tears can be divided into full tear and partial tear according to tear thickness.Partial rotator cuff tear is partial tears of rotator cuff thickness.Conservative treatment is usually preferred.Drug injection in conservative therapy is an important way to treat this kind of tendon disease.Among the most commonly used drug injections in clinic are corticosteroids,sodium hyaluronate and platelet-rich plasma(PRP).PRP is a platelet concentrate extracted from fresh whole blood after centrifugation.It is a commonly used biological agent at present.It has been widely used in clinical repair of various tissues and has achieved certain effects,especially in tendon diseases.However,the efficacy,safety and tear type of PRP in the treatment of partial rotator cuff tear remain to be explored. This review synthesized evidence from recent literature on PRP for partial-thickness rotator cuff tears (PTRCTs). It delineated the efficacy of PRP in pain and functional recovery, its safety profile, indications stratified by tear characteristics (location and grade), and its long-term benefits benchmarked against corticosteroids and other injectables. The analysis may provide critical insights to guide the rational clinical application of PRP.

表1 PRP注射治疗PTRCTs的研究
Table 1 Study on PRP injection for the treatment of PTRCTs
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