| [1] |
《中成药治疗优势病种临床应用指南》标准化项目组, 姜泉, 赵岩. 中成药治疗类风湿关节炎临床应用指南（2022年）[J]. 中国中西医结合杂志, 2023, 43（3）: 261-273.
|
| [2] |
Lee DM, Weinblatt ME. Rheumatoid arthritis[J]. Lancet, 2001, 358（9285）: 903-911.
|
| [3] |
Li Y, Ding T, Chen J, et al. The protective capability of Hedyotis diffusa Willd on lupus nephritis by attenuating the IL-17 expression in MRL/lpr mice[J/OL]. Front Immunol, 2022, 13: 943827. DOI: 10.3389/fimmu.2022.943827.
|
| [4] |
Hao W, Chen Z, Yuan Q, et al. Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation[J]. Int J Biol Macromol, 2022, 219: 730-739.
|
| [5] |
Wang J, Chen S, Zhang J, et al. Scutellaria baicalensis Georgi is a promising candidate for the treatment of autoimmune diseases[J/OL]. Front Pharmacol, 2022, 13: 946030. DOI: 10.3389/fphar.2022.946030.
|
| [6] |
Wang Y, Chen S, Du K, et al. Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis[J/OL]. J Ethnopharmacol, 2021, 279: 114368. DOI: 10.1016/j.jep.2021.114368.
|
| [7] |
黄帝内经素问[M]. 北京: 人民卫生出版社, 1963: 197.
|
| [8] |
刘蔚翔, 姜泉. 中西医治疗类风湿关节炎的研究进展[J]. 中华中医药杂志, 2022, 37（12）: 7251-7257.
|
| [9] |
刘蔚翔, 姜泉. 类风湿关节炎"湿、热、瘀"病机理论探析[J]. 中医杂志, 2020, 61（24）: 2148-2153.
|
| [10] |
赵越, 晏菁遥, 黄闰月, 等. 近十年治疗类风湿关节炎文献的中医证候分布与遣方用药规律分析[J]. 中华中医药学刊, 2019, 37（9）: 2168-2177.
|
| [11] |
王建, 巩勋, 唐晓颇, 等. 1602例类风湿关节炎患者中医证候分布特点的多中心横断面调查[J]. 中医杂志, 2018, 59（11）: 963-967.
|
| [12] |
曹玉举. 娄多峰"虚、邪、瘀"理论论治类风湿关节炎[J]. 中华中医药杂志, 2018, 33（2）: 569-571.
|
| [13] |
Chen Z, Bozec A, Ramming A, et al. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis[J]. Nat Rev Rheumatol, 2019, 15（1）: 9-17.
|
| [14] |
刘蔚翔, 巩勋, 姜泉, 等. 类风湿关节炎湿热与寒湿证候的病情特点分析[J]. 中华中医药杂志, 2021, 36（2）: 1088-1091.
|
| [15] |
Tu J, Hong W, Zhang P, et al. Ontology and function of fibroblast-like and macrophage-like synoviocytes: how do they talk to each other and can they be targeted for rheumatoid arthritis therapy?[J/OL]. Front Immunol, 2018, 9: 1467. DOI: 10.3389/fimmu.2018.01467.
|
| [16] |
Wang Y, Wu H, Deng R. Angiogenesis as a potential treatment strategy for rheumatoid arthritis[J/OL]. Eur J Pharmacol, 2021, 910: 174500. DOI: 10.1016/j.ejphar.2021.174500.
|
| [17] |
Yu L, Li S, Pu L, et al. Traditional Tibetan medicine: therapeutic potential in rheumatoid arthritis[J/OL]. Front Pharmacol, 2022, 13: 938915. DOI: 10.3389/fphar.2022.938915.
|
| [18] |
Li XZ, Zhang SN. Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine[J/OL]. Chin Med, 2020, 15: 80. DOI: 10.1186/s13020-020-00363-5.
|
| [19] |
Li XZ, Zhang SN. Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction[J]. Phytother Res, 2020, 34（1）: 51-66.
|
| [20] |
Lu C, Cheng RJ, Zhang Q, et al. Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization[J/OL]. Int Immunopharmacol, 2023, 125（Pt B）: 111175. DOI: 10.1016/j.intimp.2023.111175.
|
| [21] |
de Seabra Rodrigues Dias IR, Lo HH, Zhang K, et al. Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis[J/OL]. Pharmacol Res, 2021, 170: 105696. DOI: 10.1016/j.phrs.2021.105696.
|
| [22] |
Zhang H, Liu J, Zhang P, et al. Herbal formula longteng decoction promotes the regression of synovial inflammation in collagen-induced arthritis mice by regulating type 2 innate lymphocytes[J/OL]. Front Pharmacol, 2021, 12: 778845. DOI: 10.3389/fphar.2021.778845.
|
| [23] |
Hu N, Wang C, Wang B, et al. Qianghuo Shengshi decoction exerts anti-inflammatory and analgesic via MAPKs/CREB signaling pathway[J/OL]. J Ethnopharmacol, 2022, 284: 114776. DOI: 10.1016/j.jep.2021.114776.
|
| [24] |
Wang T, Jia Q, Chen T, et al. Alleviation of synovial inflammation of juanbi-Tang on collagen-induced arthritis and TNF-tg mice model[J/OL]. Front Pharmacol, 2020, 11: 45. DOI: 10.3389/fphar.2020.00045.
|
| [25] |
Li D, Liu W, Sun S, et al. Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes[J/OL]. J Ethnopharmacol, 2023, 309: 116297. DOI: 10.1016/j.jep.2023.116297.
|
| [26] |
岳静, 王世军. 薏苡仁及其组分对佐剂性关节炎大鼠抗炎镇痛的作用及其机制[J]. 中国组织工程研究, 2023, 27（26）: 4187-4192.
|
| [27] |
Xu Q, Kong H, Ren S, et al. Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1α/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats[J/OL]. Chin Med, 2023, 18（1）: 119. DOI: 10.1186/s13020-023-00833-6.
|
| [28] |
戎嘉诚, 洪俊, 黄磊, 等. 基于网络药理学和分子对接法分析5种中药活性成分治疗心肌缺血再灌注损伤的机制[J]. 辽宁中医杂志, 2024, 51（6）: 5-10, 223-225.
|
| [29] |
Li S, Huang X, Li Y, et al. Spectrum-effect relationship in Chinese herbal medicine: current status and future perspectives[J]. Crit Rev Anal Chem, 2025, 55（2）: 353-374.
|
| [30] |
Jo S, Samarpita S, Lee JS, et al. 8-Shogaol inhibits rheumatoid arthritis through targeting TAK1[J/OL]. Pharmacol Res, 2022, 178: 106176. DOI: 10.1016/j.phrs.2022.106176.
|
| [31] |
Liu X, Wang Z, Qian H, et al. Natural medicines of targeted rheumatoid arthritis and its action mechanism[J/OL]. Front Immunol, 2022, 13: 945129. DOI: 10.3389/fimmu.2022.945129.
|
| [32] |
Rufino AT, Freitas M, Proença C, et al. Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy[J]. Med Res Rev, 2024, 44（2）: 497-538.
|
| [33] |
Shen P, Lin W, Deng X, et al. Potential implications of quercetin in autoimmune diseases[J/OL]. Front Immunol, 2021, 12: 689044. DOI: 10.3389/fimmu.2021.689044.
|
| [34] |
张广辉, 魏琴, 李坤, 等. 基于Wnt3a/β-catenin通路探讨马钱子总生物碱对类风湿关节炎大鼠滑膜细胞凋亡的影响[J]. 现代免疫学, 2025, 45（5）: 511-518.
|
| [35] |
Yan Y, Zhang LB, Ma R, et al. Jolkinolide B ameliorates rheumatoid arthritis by regulating the JAK2/STAT3 signaling pathway[J/OL]. Phytomedicine, 2024, 124: 155311. DOI: 10.1016/j.phymed.2023.155311.
|
| [36] |
Shirai T, Nakai A, Ando E, et al. Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex[J/OL]. Sci Immunol, 2023, 8（81）: eadc9324. DOI: 10.1126/sciimmunol.adc9324.
|
| [37] |
Correa LB, Almeida Pádua T, Alabarse PVG, et al. Protective effect of methyl gallate on murine antigen-induced arthritis by inhibiting inflammatory process and bone erosion[J]. Inflammopharmacology, 2022, 30（1）: 251-266.
|
| [38] |
Shen Y, Teng L, Qu Y, et al. Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways[J/OL]. J Ethnopharmacol, 2022, 284: 114791. DOI: 10.1016/j.jep.2021.114791.
|
| [39] |
Bischoff-Kont I, Primke T, Niebergall LS, et al. Ginger constituent 6-shogaol inhibits inflammation- and angiogenesis-related cell functions in primary human endothelial cells[J/OL]. Front Pharmacol, 2022, 13: 844767. DOI: 10.3389/fphar.2022.844767.
|
| [40] |
Nazari-Khanamiri F, Ghasemnejad-Berenji M. Resveratrol may ameliorate rheumatoid arthritis via the STAT3/HIF-1/VEGF molecular pathway[J/OL]. J Food Biochem, 2022, 46（8）: e14182. DOI: 10.1111/jfbc.14182.
|
| [41] |
Tao Y, Liu J, Li M, et al. Abelmoschus manihot （L. ） medik. seeds alleviate rheumatoid arthritis by modulating JAK2/STAT3 signaling pathway[J/OL]. J Ethnopharmacol, 2024, 325: 117641. DOI: 10.1016/j.jep.2023.117641.
|
| [42] |
Zhan H, Chen R, Zhong M, et al. Exploring the pharmacological mechanisms and key active ingredients of total flavonoids from Lamiophlomis rotata （Benth. ） Kudo against rheumatoid arthritis based on multi-technology integrated network pharmacology[J/OL]. J Ethnopharmacol, 2023, 317: 116850. DOI: 10.1016/j.jep.2023.116850.
|
| [43] |
Sun YW, Bao Y, Yu H, et al. Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa[J/OL]. Int Immunopharmacol, 2020, 83: 106384. DOI: 10.1016/j.intimp.2020.106384.
|
| [44] |
Wu JY, Chen YJ, Fu XQ, et al. Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling[J/OL]. BMC Complement Med Ther, 2022, 22（1）: 73. DOI: 10.1186/s12906-022-03553-w.
|
| [45] |
Zhang L, Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony[J/OL]. Pharmacol Ther, 2020, 207: 107452. DOI: 10.1016/j.pharmthera.2019.107452.
|
| [46] |
Bu Y, Wu H, Deng R, et al. The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN[J]. Inflammopharmacology, 2022, 30（3）: 1047-1062.
|
| [47] |
Luo S, Li H, Liu J, et al. Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund’s adjuvant-induced arthritis[J/OL]. Chem Biol Interact, 2020, 319: 108984. DOI: 10.1016/j.cbi.2020.108984.
|
| [48] |
Meng M, Yue Z, Chang L, et al. Anti-rheumatoid arthritic effects of Paris saponin VII in human rheumatoid arthritis fibroblast-like synoviocytes and adjuvant-induced arthritis in rats[J/OL]. Front Pharmacol, 2021, 12: 683698. DOI: 10.3389/fphar.2021.683698.
|
| [49] |
Meng N, Xie HX, Hou JR, et al. Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs[J]. Chin J Nat Med, 2022, 20（3）: 229-240.
|
| [50] |
Li Z, Chen M, Wang Z, et al. Berberine inhibits RA-FLS cell proliferation and adhesion by regulating RAS/MAPK/FOXO/HIF-1 signal pathway in the treatment of rheumatoid arthritis[J]. Bone Joint Res, 2023, 12（2）: 91-102.
|
| [51] |
Cai J, Zhang LC, Zhao RJ, et al. Chelerythrine ameliorates rheumatoid arthritis by modulating the AMPK/mTOR/ULK-1 signaling pathway[J/OL]. Phytomedicine, 2022, 104: 154140. DOI: 10.1016/j.phymed.2022.154140.
|
| [52] |
Ma XN, Feng W, Li N, et al. Leonurine alleviates rheumatoid arthritis by regulating the Hippo signaling pathway[J/OL]. Phytomedicine, 2024, 123: 155243. DOI: 10.1016/j.phymed.2023.155243.
|