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中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 225 -230. doi: 10.3877/cma.j.issn.1674-134X.2024.02.010

综述

成纤维样滑膜细胞在类风湿关节炎发病机制中的作用
王帆1, 余辉1, 谢佳乐1, 许焕焕2, 马瑞1, 依日夏提·艾海提3, 许珂3, 许鹏3,†()   
  1. 1. 716000　延安大学医学院；710054　西安交通大学附属红会医院关节外科
    2. 716000　延安大学医学院
    3. 710054　西安交通大学附属红会医院关节外科
  • 收稿日期:2023-11-25 出版日期:2024-04-01
  • 通信作者: 许鹏

Role of fibroblast-like synoviocytes in pathogenesis of rheumatoid arthritis

Fan Wang1, Hui Yu1, Jiale Xie1, Huanhuan Xu2, Rui Ma1, Aihaiti Yirixiati·3, Ke Xu3, Peng Xu3,†()   

  1. 1. Medical School of Yan’an University, Yan’an 716000, China; Department of Joint Surgery, Honghui Hospital, Xi＇an Jiaotong University, Xi＇an 710054, China
    2. Medical School of Yan’an University, Yan’an 716000, China
    3. Department of Joint Surgery, Honghui Hospital, Xi＇an Jiaotong University, Xi＇an 710054, China
  • Received:2023-11-25 Published:2024-04-01
  • Corresponding author: Peng Xu
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引用本文：

王帆, 余辉, 谢佳乐, 许焕焕, 马瑞, 依日夏提·艾海提, 许珂, 许鹏. 成纤维样滑膜细胞在类风湿关节炎发病机制中的作用[J/OL]. 中华关节外科杂志(电子版), 2024, 18(02): 225-230.

Fan Wang, Hui Yu, Jiale Xie, Huanhuan Xu, Rui Ma, Aihaiti Yirixiati·, Ke Xu, Peng Xu. Role of fibroblast-like synoviocytes in pathogenesis of rheumatoid arthritis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(02): 225-230.

类风湿性关节炎(RA)是一种以慢性、对称性、多发性滑膜关节炎为主要临床表现的系统性自身免疫性疾病，其发病机制目前尚不完全清楚。近年来，随着对RA细胞和分子生物学机制的不断探索，许多研究都聚焦于成纤维样滑膜细胞(FLS)，其通过分泌多种炎症因子在RA发生发展过程中起到了至关重要的作用。因此对于RA的治疗方法也从传统的非甾体抗炎药(NSAIDs)、糖皮质激素和改变病情抗风湿药(DMARDs)转变为针对细胞因子的生物靶向药物，但这些药物不可避免地会产生相应的副作用，因此，迫切需要新的、安全有效的治疗方法缓解RA患者的病痛。本文从炎症，自噬和凋亡三个方面综述了RA-FLSs对RA的影响，旨在为后续基础研究及临床工作提供帮助。

关键词: 关节炎，类风湿, 滑膜细胞, 炎症, 自噬, 细胞凋亡, 治疗学

Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic, symmetrical, polyarthritis of the synovium as the main clinical manifestation, and its pathogenesis is not fully understood. In recent years, with the continuous exploration of RA cells and molecular biological mechanisms, many studies have focused on fibroblast-like synoviocytes (FLSs), which play a crucial role in the development of RA through the secretion of various inflammatory factors. As a result, there has been a shift in the treatment of RA from traditional non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and disease-modifying anti-rheumatic drugs (DMARDs) to biologically targeted drugs that target cytokines, but these drugs inevitably produce corresponding side effects, so there is an urgent need for new, safe and effective treatments to alleviate the suffering of RA patients. This review overviewed the effects of RA-FLSs on RA in terms of inflammation, autophagy and apoptosis, aiming to provide help for the subsequent basic research and clinical work.

Key words: Arthritis, rheumatoid, Synoviocytes, Inflammation, Autophagy, Apoptosis, Therapeutics
图1 成纤维样滑膜细胞在类风湿性关节炎中的作用示意图
Figure 1 Diagram of function of fibroblast-like synovial cells in rheumatoid arthritis
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