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中华关节外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 607 -612. doi: 10.3877/cma.j.issn.1674-134X.2023.05.002

临床论著

老年髋部骨折术后便秘的影响因素及其列线图预测模型
刘丹丹, 宋鸣, 李霞, 徐夏君()   
  1. 223002 淮安市第二人民医院
  • 收稿日期:2023-02-02 出版日期:2023-10-01
  • 通信作者: 徐夏君

Influencing factors of postoperative constipation in elderly hip fractures and nomogram prediction model

Dandan Liu, Ming Song, Xia Li, Xiajun Xu()   

  1. The Second People's Hospital of Huai'an, Huai'an 223002, China
  • Received:2023-02-02 Published:2023-10-01
  • Corresponding author: Xiajun Xu
引用本文:

刘丹丹, 宋鸣, 李霞, 徐夏君. 老年髋部骨折术后便秘的影响因素及其列线图预测模型[J/OL]. 中华关节外科杂志(电子版), 2023, 17(05): 607-612.

Dandan Liu, Ming Song, Xia Li, Xiajun Xu. Influencing factors of postoperative constipation in elderly hip fractures and nomogram prediction model[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 607-612.

目的

分析影响老年髋部骨折患者术后便秘的影响因素,并据此构建老年髋部骨折患者术后便秘的列线图模型,为个性化防治老年髋部骨折患者术后便秘提供帮助。

方法

按纳入排除标准选取2020年2月至2022年2月期间淮安市第二人民医院手术治疗的髋部骨折患者131例。纳入标准:年龄≥60岁,骨折前可行走,等于或低于身体高度摔倒,伤后24 h内入院。排除标准:全身多处骨折或病理性骨折,濒危患者,合并多脏器损伤。根据术后是否便秘分为便秘组与非便秘组,比较两组间一般资料[性别、年龄、身体质量指数(BMI)];既往病史(高血压、心脏病、糖尿病、脑血管疾病);手术方式(骨钉修复、全髋关节置换、部分髋关节置换);术中情况(麻醉方式、手术方式、手术时长、术中出血量);术后卧床时间、是否使用益生菌等资料。根据logistic回归分析影响老年髋部骨折患者术后便秘的影响因素,采用R语言根据logistic筛选的影响因素构建评估髋部骨折患者术后便秘风险的列线图模型,并评估模型区分度与准确度。

结果

131例患者发生便秘者为67例,便秘发生率为51.2%;便秘组与非便秘组性别、BMI、吸烟、饮酒、高血压、心脏病、糖尿病、脑血管疾病、手术方式、麻醉方式、手术时长、术中出血量比较差异无统计学意义(均为P>0.05);与非便秘组相比,便秘组年龄、术前便秘比例、术后卧床时间升高、使用益生菌比例降低(t=6.816、χ2=35.503、t=15.956、χ2=40.663,均为P<0.05);年龄增加、有术前便秘、术后卧床时间延长、未使用益生菌是影响髋部骨折患者术后便秘发生的危险因素[优势比(OR)=1.251、22.365、10.220、0.030,均为P<0.05)];以年龄、术后卧床时间、使用益生菌、术前便秘4项影响因素构建预测的列线图模型的区分度与准确度较高。

结论

基于髋部骨折患者年龄、术后卧床时间、是否使用益生菌、术前是否便秘因素构建的列线图模型对髋部骨折患者术后是否发生便秘具有较高的预测价值,可为临床髋部骨折患者术后便秘的筛查提供帮助。

Objective

To analyze the influencing factors of postoperative constipation in elderly patients with hip fracture, and construct a nomograph model of postoperative constipation in elderly patients with hip fracture, so as to provide help for personalized prevention and treatment of postoperative constipation in elderly patients with hip fracture.

Methods

A total of 131 patients with hip fracture admitted to The Second People's Hospital of Huai'an Hospital from February 2020 to February 2022 were selected by inclusion and exclusion criteria. Inclusion criteria: age≥60 years, ambulatory before bone fractures, falling height ≤body height, admission is within 24h. Exclusion criteria: multiple fractures or pathologic fractures, patients in critical condition, multiple organ injuries. The enrolled patients were grouped into constipation group and non constipation group according to whether they were constipation after operation. The general data [gender, age, body mass index (BMI)], past medical history (hypertension, heart disease, diabetes, cerebrovascular disease), operation methods (bone nail repair, total hip replacement, partial hip replacement), intraoperative conditions (anesthesia mode, operation methods, operation duration, intraoperative blood loss), time in bed after operation, use of probiotics and other data were compared between the two groups. According to the logistic regression analysis, the influencing factors of postoperative constipation in elderly hip fracture patients were analyzed, the R language was applied to construct an nomograph model to evaluate the risk of postoperative constipation in patients with hip fracture according to the influencing factors screened by the statistics, and the model discrimination and accuracy were evaluated.

Results

Sixty-seven of 131 patients had constipation, and the incidence of constipation was 51.2%; there was no obvious difference between constipation group and non constipation group in gender, BMI, smoking, drinking, hypertension, heart disease, diabetes, cerebrovascular disease, operation mode, anesthesia mode, operation duration and intraoperative blood loss (all P>0.05). Compared with the non-constipation group, age, proportion of constipation before surgery, and time in bed after surgery increased, and the proportion of probiotics usage decreased in the constipation group (t=6.816, χ2=35.503, t=15.956, χ2=40.663, all P<0.05). Advanced age, constipation before surgery, prolonged bed rest after surgery, and no probiotics were risk factors for postoperative constipation in patients with hip fracture [odds ratio(OR)=1.251, 22.365, 10.220, 0.030, all P <0.05]. The nomogram model based on age, bed time after operation, probiotics use, and preoperative constipation had a high discrimination and accuracy.

Conclusions

The nomograph model which is based on the age of patients with hip fracture, time in bed after operation, use of probiotics and constipation before operation, has a high predictive value for whether constipation will occure after hip fracture. The nomograph model can provide help for the screening of postoperative constipation in patients with hip fracture.

表1 患者的一般临床资料
Table 1 Clinical data of the patients
项目Items 总人数Overall numbers 便秘组Constipation group 非便秘组Non-constipation group 统计值Statistical values P
例数Number of cases 131 67 64    
性别Gender[例(%)]          
男Male 65 32(47.8) 33(51.6) χ2=0.189 >0.05
女Female 66 35(52.2) 31(48.4)    
年龄[岁,(±s)]Age[years,(±s)] 73.4±3.5 69.6±3.0 t=6.816 <0.001
BMI[kg/m2,(±s)]   22.4±1.4 22.6±1.4 t=0.533 >0.05
吸烟[例(%)]Smoking          
是Yes 49 24(35.8 ) 25(39.1 ) χ2=0.147 >0.05
否No 82 43(64.2 ) 39(60.9 )    
饮酒[例(%)]Drinking          
是Yes 58 31(46.3) 27(42.2) χ2=0.221 >0.05
否No 73 36(53.7) 37(57.8)    
术前便秘Preoperative constipation[例(%)]          
是Yes 43 38(56.7) 5(7.8) χ2=35.503 <0.001
否No 88 29(43.3) 59(92.2)    
高血压[例(%)]Hypertension          
是Yes 66 30(44.8) 36(56.3) χ2=1.724 >0.05
否No 65 37(55.2) 28(43.7)    
心脏病[例(%)]Heart disease          
是Yes 39 18(26.9) 21(32.8) χ2=0.554 >0.05
否No 92 49(73.1) 43(67.2)    
糖尿病[例(%)]Diabetes          
是Yes 41 19(28.4) 22(34.4) χ2=0.551 >0.05
否No 90 48(71.6) 42(65.6)    
脑血管疾病[例(%)]Cerebrovascular diseases          
是Yes 23 10(14.9) 13(20.3) χ2=0.656 >0.05
否No 108 57(85.1) 51(79.7)    
手术方式[例(%)]Methods of operation          
骨钉修复Nail repair 38 18(26.9) 20(31.3)    
全髋关节置换Total hip replacement 31 15(22.4) 16(25.0) χ2=0.650 >0.05
部分髋关节置换Partial hip replacement 62 34(50.7) 28(43.7)    
麻醉方式[例(%)]Methods of anesthesia          
蛛网膜下腔-硬膜外联合Subarachnoid-epidural anesthesia 37 18(26.9) 19(29.7) χ2=0.129 >0.05
全身麻醉General anesthesia 94 49(73.1) 45(70.3)    
手术时长[min,(±s)]Operation duration   98.8±9.2 99.5±9.6 t=0.475 >0.05
术中出血量[ml,(±s)]Intraoperative blood loss   351.5±50.3 343.3±51.5 t=0.927 >0.05
术后卧床时间[d,(±s)]Postoperative time in bed   7.6±0.9 5.4±0.7 t=15.956 <0.001
使用益生菌[例(%)]Use of probiotics          
是Yes 61 13(19.4) 48(75.0) χ2=40.663 <0.001
否No 70 54(80.6) 16(25.0)    
表2 髋部骨折患者术后便秘logistic回归分析
Table 2 Logistic regression analysis of postoperative constipation in patients with hip fracture
图1 髋部骨折患者术后便秘的列线图模型
Figure 1 Nomogram model of postoperative constipation in patients with hip fracture
图2   ROC曲线评估髋部骨折患者术后便秘发生模型的区分度
Figure 2 Evaluation of the differentiation of postoperative constipation models in patients with hip fracture by ROC
图3 髋部骨折患者术后便秘发生模型的校准曲线注:actual probablility-实际概率;predicted Pr-预测概率
Figure 3 Calibration curve of postoperative constipation model in patients with hip fractureNote:Pr- probablility
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