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中华关节外科杂志(电子版) ›› 2021, Vol. 15 ›› Issue (03) : 318 -323. doi: 10.3877/cma.j.issn.1674-134X.2021.03.009

综述

度洛西汀治疗骨关节炎疼痛研究进展
鲍哲明1, 单青2, 李晨3, 陈孟莉2,()   
  1. 1. 100089 北京,中国人民解放军总医院医疗保障中心药剂科;250031 济南,中国人民解放军联勤保障部队第960医院骨科
    2. 100089 北京,中国人民解放军总医院医疗保障中心药剂科
    3. 100089 北京,中国人民解放军总医院创新医学部转化医学试验室
  • 收稿日期:2020-04-01 出版日期:2021-06-01
  • 通信作者: 陈孟莉
  • 基金资助:
    军队课题基金(16BJZ20)

Advancement of duloxetine in treatment of osteoarthritis pain

Zheming Bao1, Qing Shan2, Chen Li3, Mengli Chen2,()   

  1. 1. Pharmacy Department, Chinese PLA General Hospital, Beijing 100089, China; Orthopedics department, 960th Hospital of PLA Joint Service Support Force, Jinan 250031, China
    2. Pharmacy Department, Chinese PLA General Hospital, Beijing 100089, China
    3. Translational Medicine Laboratory, Chinese PLA General Hospital, Beijing 100089, China
  • Received:2020-04-01 Published:2021-06-01
  • Corresponding author: Mengli Chen
引用本文:

鲍哲明, 单青, 李晨, 陈孟莉. 度洛西汀治疗骨关节炎疼痛研究进展[J/OL]. 中华关节外科杂志(电子版), 2021, 15(03): 318-323.

Zheming Bao, Qing Shan, Chen Li, Mengli Chen. Advancement of duloxetine in treatment of osteoarthritis pain[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2021, 15(03): 318-323.

目前针对骨关节炎的药物治疗主要目的是缓解疼痛,提高关节功能。骨关节炎慢性持续性疼痛往往伴随有神经性疼痛的特点以及中枢敏感化现象。目前认为度洛西汀作为5-羟色胺和去甲肾上腺素再摄取抑制剂,能通过下行疼痛调节系统治疗神经性疼痛,同时一些研究中也发现了度洛西汀在治疗疼痛中存在的抗炎作用。在治疗骨关节炎疼痛的临床实验和研究中,度洛西汀能够有效缓解骨关节炎疼痛,并且具有良好的安全性和耐受性。在此,本文就度洛西汀治疗骨关节炎疼痛相关研究报道作一综述。

Drug treatments for osteoarthritis are primarily targeted at relieving pain, improving joint function.Chronic persistent pain in osteoarthritis is often accompanied by neuropathic pain and central sensitization. Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is used in the treatment of neuropathic pain through the descending pain modulatorysystem, and some studies have also found the anti-inflammatory activity of duloxetine in the treatment of pain. Duloxetine has been shown to be effective in relieving osteoarthritis pain in reported clinical trials and studies with good safety and tolerability profiles. This review mainly aimed at the related reports of duloxetine in the treatment of osteoarthritis pain.

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