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中华关节外科杂志(电子版) ›› 2021, Vol. 15 ›› Issue (02) : 214 -218. doi: 10.3877/cma.j.issn.1674-134X.2021.02.013

所属专题: 文献

综述

甲状旁腺激素在骨软骨组织中的应用进展
陈玉书1, 谢慧峰1, 张燕红2,(), 白波1, 陈艺1, 张姝江1   
  1. 1. 510120 广州医科大学附属第一医院广东省骨科矫形与植入材料重点实验室
    2. 528300 佛山,南方医科大学顺德医院创伤关节外科
  • 收稿日期:2020-11-08 出版日期:2021-04-01
  • 通信作者: 张燕红
  • 基金资助:
    广东省教育厅特色创新类项目(2017KTSCX154)

Progress of parathyroid hormone on bone and cartilage tissues

Yushu Chen1, Huifeng Xie1, Yanhong Zhang2,(), Bo Bai1, Yi Chen1, Shujiang Zhang1   

  1. 1. Department of Orthopaedic Surgery, Orthopedics Implantation Key Lab of Guangdong Province, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
    2. Department of Orthopaedic Surgery, Shunde Hospital of Southern Medical University, Foshan 528300, China
  • Received:2020-11-08 Published:2021-04-01
  • Corresponding author: Yanhong Zhang
引用本文:

陈玉书, 谢慧峰, 张燕红, 白波, 陈艺, 张姝江. 甲状旁腺激素在骨软骨组织中的应用进展[J/OL]. 中华关节外科杂志(电子版), 2021, 15(02): 214-218.

Yushu Chen, Huifeng Xie, Yanhong Zhang, Bo Bai, Yi Chen, Shujiang Zhang. Progress of parathyroid hormone on bone and cartilage tissues[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2021, 15(02): 214-218.

甲状旁腺激素(PTH)是亲骨性内分泌激素之一,参与多种细胞生物学过程。目前已有研究表明PTH可能通过多种信号通路参与骨形成,并可抑制软骨细胞的肥大分化及凋亡,刺激其增殖,从而可适度保护软骨细胞。本文通过对PTH在骨软骨组织的作用机制的研究进展进行综述。

Parathyroid hormone (PTH) is one of the osteophilic endocrine hormones, which is involved in a variety of cellular biological processes. Previous studies have shown that PTH can inhibit the hypertrophic differentiation and apoptosis of chondrocytes and stimulate their proliferation, which has a moderate protection function on the cartilage cells by multiple signal pathways. In this paper, the mechanism of PTH in osteochondral tissue was reviewed.

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