切换至 "中华医学电子期刊资源库"

中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 348 -352. doi: 10.3877/cma.j.issn.1674-134X.2019.03.015

所属专题: 文献

综述

强直性脊柱炎的骨化研究进展
万文凯1, 徐一宏1, 徐卫东1,()   
  1. 1. 200433 上海,海军军医大学附属长海医院骨科(关节外科)
  • 收稿日期:2018-12-24 出版日期:2019-06-01
  • 通信作者: 徐卫东
  • 基金资助:
    国家自然科学基金(81672126,81871751)

Progress in ossification of ankylosing spondylitis

Wenkai Wan1, Yihong Xu1, Weidong Xu1,()   

  1. 1. Department of Joint & Bone Surgery, Changhai Hospital, the First Affiliated Hospital of the Second Military Medical University, Shanghai 200433, China
  • Received:2018-12-24 Published:2019-06-01
  • Corresponding author: Weidong Xu
  • About author:
    Corresponding author: Xu Weidong, Email:
引用本文:

万文凯, 徐一宏, 徐卫东. 强直性脊柱炎的骨化研究进展[J]. 中华关节外科杂志(电子版), 2019, 13(03): 348-352.

Wenkai Wan, Yihong Xu, Weidong Xu. Progress in ossification of ankylosing spondylitis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(03): 348-352.

病理性骨化是强直性脊柱炎最主要的特点之一。目前有很多关于强直性脊柱炎骨化的研究,包括炎症与骨化的关系、骨化信号通路及Wnt信号通路等。从不同的方面来研究强直性脊柱炎的骨化过程,彻底弄清其骨化的机制,对治疗强直性脊柱炎有着重要的意义。

Pathological ossification is one of the most important features of ankylosing spondylitis. There are many studies on the ossification of ankylosing spondylitis, including the relationship between inflammation and ossification, ossification signal pathway and Wnt signaling pathway. To study the ossification process of ankylosing spondylitis from different aspects and thoroughly understand the mechanism of ossification, it is of great significance for the treatment of ankylosing spondylitis.

[1]
郝晓娟,杜娟丽,张强,等.以急性前葡萄膜炎为首发症状的强直性脊柱炎43例临床分析[A].陕西医学杂志,2017,46(1):77-78.
[2]
Ramiro S,Stolwijk C,Van Tubergen A, et al. Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study[J]. Ann Rheum Dis, 2015, 74(1): 52-59.
[3]
Poddubnyy D,Rudwaleit M,Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis[J]. Ann Rheum Dis, 2011, 70(8): 1369-1374.
[4]
Maksymowych WP,Chiowchanwisawakit P,Clare T, et al.Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis:evidance of a relationship between in flammation and new bone formation [J].Arthritis Rheum, 2009, 60:93-102.
[5]
厉小梅,李向培,汪国生,等.关节炎患者血清肿瘤坏死因子α的检测及意义[J].安徽医学,2002,23(6):12-13.
[6]
Ueno T,Kagawa T,Kanou M, et al. Immunolocalization of vascular endothelial growth factor during heterotopic bone formation induced from grafted periosteum[J]. Ann Plast Surg, 2004,53(2):150-154.
[7]
古洁若,张汉伟,赵丽珂,等.基质金属蛋白酶-3在强直性脊柱炎中的作用和意义探讨[J].中国药物与临床,2004,4(4):270-276.
[8]
陈鹏,刘宏潇.Th17/IL-17炎症轴介导强直性脊柱炎炎症的机制研究[J].现代中西医结合杂志,2015,24(7):796-798.
[9]
Shi E,Sugiyama T,Tanaka H, et al.Possible involvement of vitamin D receptor gene polymorphism in male patients with ossification of spinal ligaments [J]. J Bone Miner Metab, 2001, 19(5): 308-311.
[10]
He Tao,Huang Yan,Zhang Chen, et al. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis [J]. Oncotarget, 2017, 8(57): 96993-97008.
[11]
Hamon N,Inman RD,Learch TJ, et al.The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis [J].Arthritis & Rheum, 2013, 65 (10): 2645-2654.
[12]
Ramiro S,StolwiJk C,Tubergen AV, et al..Evolution of radiographic damage in ankylosing spondylitis:a 12 year prospective follow-up of the OASIS study [J].Ann Rheum Dis, 2015, 74 (7): 1482.
[13]
Zhao JZ,Yuan W,Tao CS, et al. M2 polarization of monocytes in ankylosing spondylitis and relationship with inflammation and structural damage[J]. APMIS, 2017, 125(12): 1070-1075.
[14]
Moon RT,Bowerman B,Boutros M, et al. The promise and perils of Wnt signaling through β-catenin. Science, 2002, 296 (5573):1644–1646.
[15]
Kook SH,Heo JS,Lee JC. Crucial roles of canonical Runx2一de-pendent pathway on Wntl-induced osteoblastic differentiation of human periodontal ligament fibroblasts[J]. Mol Cell Biochem, 2015, 402(1/2): 213-223.
[16]
Maeda K,Kobayashi Y,Udagawa N, et al. Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis[J]. Nat Med, 2012, 18(3): 405-412.
[17]
Solmaz D,Uslu S,Kozaci D, et al. Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: periostin may be associated with the Wnt pathway[J]. Int J Rheum Dis, 2018, 21(2): 502-509.
[18]
宋颖钰,崔阳,张晓.强直性脊柱炎炎性骨破坏和病理性骨化的信号转导机制[J].中国骨质疏松杂志,2015,21(9):1132-1137.
[19]
Huelsken J,Vogel R,Erdmann B, et al. β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin[J].Cell, 2001, 105(4):533-545.
[20]
Mao J,Wang J,Liu B, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway[J]. Molecular Cell, 2001, 7(4):801-809.
[21]
Haynes KR,Pettit AR,Duan R, et al. Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors[J]. Arthritis Research & Therapy (Online), 2012, 14(6):R253-R253.
[22]
Wanqing Xie,LiJiang Zhou,Shan Li, et al. Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis [J].Ann New York Acad Sci, 2016, 1364(1): 25-31.
[23]
Appel H,Ruiz-Heiland G,Listing J, et al. Altered skeletal expression of sclerostin and its Link to radiographic progression in ankylosing spondylitis[J]. Arthritis Rheum, 2009, 60(11): 3257-3262.
[24]
蔡颜嵘,徐卫东.基于强直性脊柱炎骨化相关信号通路探讨其炎症与骨化的关系[J].中华风湿病学杂志,2015,19(6):428-431.
[25]
Biver E,Hardouin P,Caverzasio J. The 'bone morphogenic proteins’ pathways in bone and joint diseases: translational perspectives from physiopathology to therapeutic targets [J]. Cytokine Growth Factor Rev, 2013, 24(1): 69-81.
[26]
Vandooren B,Cantaert T,Noordenbos T, et al. The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation [J].Arthritis Rheumatism, 2008, 58(3): 718-729.
[27]
刘宏潇,冯兴华,李丽,等.强直性脊柱炎成纤维细胞增殖细胞周期及凋亡的初步研究[J].中华风湿病学杂志,2005,9(12):758-760.
[28]
宋颖钰,崔阳,张晓.强直性脊柱炎炎性骨破坏和病理性骨化的信号转导机制[J].中国骨质疏松杂志,2015,21(9):1132-1137.
[29]
高根德,刘迅,王萧枫,等.培养的人强直性脊柱炎成纤维细胞的超微结构[J].中国中医骨伤科杂志,2001,9(5):30-31, 67.
[30]
Dong M,Jiao GJ,Liu HC, et al. Biological Silicon stimulates collagen type 1 and osteocalcin synthesis in human Osteoblast-Like cells through the BMP-2/Smad/RUNX2 signaling pathway[J]. Biol Trace Elem Res, 2016, 173(2): 306-315.
[31]
Yuan B,Wu ZM. MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis[J]. Oncol Lett, 2018, 15(3): 3281-3286.
[32]
Gandavarapu NR,Mariner PD,Schwartz MP, et al. Extracellular matrix protein adsorption to phosphate-functionalized gels from serum promotes osteogenic differentiation of human mesenchymal stem cells[J]. Acta Biomater, 2013, 9(1): 4525-4534.
[33]
张秀梅,崔亚洲,韩金祥.强直性脊柱炎致病机制研究进展[J].国际骨科学杂志,2011,32(3):170-172, 175.
[34]
Hofbauer LC,Khosla S,Dunstan CR, et al. The role of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption [J].J Bone Miner Res, 2000, 15(1): 2-12.
[35]
赵伟,黄烽.护骨素在强直性脊柱炎外周关节骨质破坏病理机制中的作用[J].中华风湿病学杂志,2005, 9(6):329-333+385.
[36]
Kong YY,Feige U,Sarosi I, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand[J]. Nature, 1999, 402(6759): 304-309.
[37]
韦蓉梅,董丽平,吴红慧,等.强直性脊柱炎患者骨代谢生化指标和RANKL-RANK-OPG系统表达之间的相关性[J].现代生物医学进展,2013,13(13):2528-2531+2546.
[1] 韩圣瑾, 周正武, 翁云龙, 黄鑫. 碳酸氢钠林格液联合连续性肾脏替代疗法对创伤合并急性肾损伤患者炎症水平及肾功能的影响[J]. 中华危重症医学杂志(电子版), 2023, 16(05): 376-381.
[2] 韩媛媛, 热孜亚·萨贝提, 冒智捷, 穆福娜依·艾尔肯, 陆晨, 桑晓红, 阿尔曼·木拉提, 张丽. 组合式血液净化治疗对脓毒症患者血清炎症因子水平和临床预后的影响[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 272-278.
[3] 魏徐, 张鸽, 伍金林. 新生儿脓毒症相关性凝血病的监测和治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 379-386.
[4] 陈大敏, 曹晓刚, 曹能琦. 肥胖对胃癌患者手术治疗效果的影响研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 651-653.
[5] 贾成朋, 王代宏, 陈华, 孙备. 可切除性胰腺癌预后术前预测模型的建立及应用[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 566-570.
[6] 伍学成, 李远伟, 袁武雄, 王建松, 石泳中, 卢强, 李卓, 陈佳, 刘哲, 滕伊漓, 高智勇. 炎症介质谱联合降钙素原在尿源性脓毒血症中的诊断价值[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 476-480.
[7] 王可, 范彬, 李多富, 刘奎. 两种疝囊残端处理方法在经腹腹膜前腹股沟疝修补术中的疗效比较[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 692-696.
[8] 刘小燕, 龙乾发, 席俊秀, 杜明皓, 黄晓欢. 细胞外囊泡介导的胶质细胞交互作用对神经炎症的调节意义及研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 235-241.
[9] 许磊, 孙杰, 陈先志, 张家泉, 李旺勇, 冯其柱, 王琦. 血液净化治疗在高血脂性重症胰腺炎中的应用[J]. 中华肝脏外科手术学电子杂志, 2023, 12(04): 464-468.
[10] 苗软昕, 乔晞. Toll样受体在脓毒症性急性肾损伤中的作用[J]. 中华肾病研究电子杂志, 2023, 12(04): 210-214.
[11] 邹勇, 顾应江, 丁昊, 杨呈浩, 陈岷辉, 蔡昱. 基于Nrf2/HO-1及NF-κB信号通路探讨葛根素对大鼠脑出血后早期炎症反应及氧化应激反应的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 271-277.
[12] 屈霄, 王靓, 陆萍, 何斌, 孙敏. 外周血炎症因子及肠道菌群特征与活动性溃疡性结肠炎患者病情的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 466-470.
[13] 朱风尚, 舍玲, 丁永年, 杨长青. 警惕炎症性肠病与少见肠道疾病的鉴别诊断[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 273-276.
[14] 刘感哲, 艾芬. MiRNA-210通过抑制HIF-1α的表达改善大鼠血管性认知功能障碍[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 489-494.
[15] 刘天姿, 王宝军. Toll样受体4在阿尔茨海默病中的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 404-409.
阅读次数
全文


摘要