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中华关节外科杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 213 -219. doi: 10.3877/cma.j.issn.1674-134X.2019.02.014

所属专题: 文献

综述

人工关节置换术后感染的生物治疗方法及前景
李朔1, 徐一宏1, 徐卫东1,()   
  1. 1. 200433 上海长海医院
  • 收稿日期:2018-08-30 出版日期:2019-04-01
  • 通信作者: 徐卫东

Methods and prospects for biologic treatment of infection after arthroplasty

Shuo Li1, Yihong Xu1, Weidong Xu1,()   

  1. 1. Changhai Hospital, Shanghai 200433, China
  • Received:2018-08-30 Published:2019-04-01
  • Corresponding author: Weidong Xu
  • About author:
    Corresponding author: Xu Weidong, Email:
引用本文:

李朔, 徐一宏, 徐卫东. 人工关节置换术后感染的生物治疗方法及前景[J/OL]. 中华关节外科杂志(电子版), 2019, 13(02): 213-219.

Shuo Li, Yihong Xu, Weidong Xu. Methods and prospects for biologic treatment of infection after arthroplasty[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(02): 213-219.

人工关节假体术后感染是骨科临床治疗的难点、热点。目前假体周围感染(PJI)的治疗方法包括保守治疗和手术治疗,但总的治疗效果不理想。PJI生物治疗是指利用新型杀菌/抑菌剂、生物工程、组织工程等方法,通过破坏生物膜、靶向杀灭致病菌、被动免疫以及局部缓释杀菌剂等方式对PJI进行治疗的新方法。它的出现有望解决PJI治疗存在的一系列难题。本文就近年来PJI生物治疗的研究进展及应用前景进行综述。

The treatment of prosthesis joint infection(PJI) is a great challenge in orthopedics. In general, the treatment of PJI includes conservative and surgical therapy, but the overall effect is unsatisfactory.The biotherapy of PJI is a new method to treat PJI by destructing bioflims, specifically killing pathogenic bacteria and activating passive immunity through noval antibiotics, bioengineering, tissue engineering, drug delivery system and other methods. It is expected to solve a series of problems existing in PJI treatment. This article reviewed the progress and application prospect of PJI biotherapy.

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