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中华关节外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (05) : 618 -625. doi: 10.3877/ cma.j.issn.1674-134X.2024.05.009

综述

假体周围骨溶解中巨噬细胞极化的机制研究进展
张凯1,2, 乔永杰2, 林志强1, 刘健1, 邓泽群3, 谭飞1, 曾健康1, 李嘉欢1, 李培杰1, 周胜虎2,()   
  1. 1.730030 兰州,甘肃中医药大学
    2.730050 兰州,解放军联勤保障部队第九四〇医院
    3.2750004 银川,宁夏医科大学
  • 收稿日期:2024-02-18 出版日期:2024-10-01
  • 通信作者: 周胜虎
  • 基金资助:
    兰州市科技计划(2023-2-11)甘肃中医药大学导师专项(2023YXKY015)

Advances in mechanism of macrophage polarization in periprosthetic osteolysis

Kai Zhang1,2, Yongjie Qiao2, Zhiqiang Lin1, Jian Liu1, Zequn Deng3, Fei Tan1, Jiankang Zeng1, Jiahuan Li1, Peijie Li1, Shenghu Zhou2,()   

  1. 1.Gansu University of Chinese Medical, Lanzhou 730030, China
    2.The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
    3.Ningxia Medical University, Yinchuan 750004, China
  • Received:2024-02-18 Published:2024-10-01
  • Corresponding author: Shenghu Zhou
引用本文:

张凯, 乔永杰, 林志强, 刘健, 邓泽群, 谭飞, 曾健康, 李嘉欢, 李培杰, 周胜虎. 假体周围骨溶解中巨噬细胞极化的机制研究进展[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 618-625.

Kai Zhang, Yongjie Qiao, Zhiqiang Lin, Jian Liu, Zequn Deng, Fei Tan, Jiankang Zeng, Jiahuan Li, Peijie Li, Shenghu Zhou. Advances in mechanism of macrophage polarization in periprosthetic osteolysis[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(05): 618-625.

人工关节置换是骨关节病的有效治疗方式之一。虽然此治疗术后效果理想,但是术后假体周围骨溶解(PPOL)仍是导致关节置换失败的一个重要因素。其中巨噬细胞极化是诱致PPOL至关重要的因素。因此,采用非手术治疗方式调控巨噬细胞极化,进而阻遏骨溶解,治疗骨性病变成为更好的选择。本文首次阐述了巨噬细胞极化的主要代谢模式、炎症和破骨/成骨细胞之间的关系,以及潜在的信号通路。表述巨噬细胞极化机制与PPOL之间的关系以及治疗措施,巨噬细胞极化在假体周围微环境中的作用影响着假体的长期适用性。因此,可将免疫调节作为延长假体使用周期的一项干预措施,将代谢重编程作为一种新兴的潜在靶点。

Artificial joint replacement is one of the effective treatments for osteoarthropathy. Although the postoperative effect of this treatment is satisfactory, periprosthesis osteolysis is still an important factor leading to the failure of joint replacement. Among them, macrophage polarization is the most important factor to induce osteolysis around the prosthesis. Therefore, it is a better choice to regulate the polarization of macrophages by non-surgical treatment, thus preventing osteolysis and treating bone lesions. The main metabolic patterns of macrophage polarization, the relationship between inflammation and osteoclast/osteoblast,and the potential signaling pathways are described for the first time. The relationship between the mechanism of macrophage polarization and periprosthesis osteolysis as well as the therapeutic measures were described. The effect of macrophage polarization in the periprosthesis micro-environment affects the long-term applicability of the prosthesis. Therefore, immunomodulation can be used as an intervention to prolong the use of prostheses,and metabolic reprogramming can be regarded as an emerging potential target.

表1 M1型/M2型巨噬细胞特征
Table 1 Characterization of M1-type/M2-type macrophages
图1 巨噬细胞极化致PPOL(假体周围骨溶解)的3条通路 注:从左到右分别为JAK/STAT通路、Notch通路、NF-κB通路
Figure 1 Three pathways of macrophage polarization to PPOL
图2 M1/M2型巨噬细胞糖代谢的重编程 注:实线-促进,虚线-抑制;Citrate-柠檬酸;isocitrate-异柠檬酸;Succinate-琥珀酸;Fumarate-延胡索酸;Malate-苹果酸;Oxaloace-草酰乙酸;AcetyI-COA-乙酰-COA;Glutamine-谷氨酰胺;Glutamate-谷氨酸;Pyruvate-丙酮酸;Lactate-乳酸;β-Oxidation-β-氧化
Figure 2 Reprogramming of sugar metabolism in M1/M2 type macrophages
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