Mechanism of autophagy in periprosthetic osteolysis and research progress

doi:10.3877/cma.j.issn.1674-134X.2025.06.010

Abstract

Abstract:

Artificial joint replacement is an effective treatment for end-stage osteoarthritic diseases, but periprostheticosteolysis, as its major complication, seriously affects the service life of the prosthesis and the prognosis of patients. Autophagy plays an important role in the development of periprosthetic osteolysis. This paper reviewed the theories of periprosthetic osteolysis and autophagy, elaborated the role of autophagy in the development of periprosthetic osteolysis, including the induction of autophagy by wear and tear particles, the removal of wear and tear particles by autophagy, and introduced the latest research results and breakthroughs, pointing out the limitations of the current study and the future outlook, with the aim of providing references for unraveling the pathogenesis of periprosthetic osteolysis and searching for the effective therapeutic targets.

Key words: Autophagy, Osteolysis, Joint prosthesis, Osteoblasts

Jiahuan Li, Shengjie Zhang, Chenghu Ma, Jiangping Wang, Zhenhao Liu, Qifeng Song, Shenggui Li, Shenghu Zhou. Mechanism of autophagy in periprosthetic osteolysis and research progress[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(06): 714-719.

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