Study progress in pharmacodynamic mechanism of Chinese medicine on rheumatoid arthritis

doi:10.3877/cma.j.issn.1674-134X.2025.06.009

Abstract

Abstract:

Rheumatoid arthritis (RA) is an autoimmune disease that involves the small peripheral joints, and the main lesions include inflammatory reaction, synovial cell proliferation and synovial neovascularization. According to Chinese medicine, "dampness, heat and stasis" are the main theories of RA’s pathogenesis. Chinese medicine compound preparation and its main active ingredients can inhibit the inflammatory reaction, the proliferation of fibroblast-like synoviocytes (FLS), and synovial blood vessel neovascularization, thus preventing the deterioration of RA. Therefore, it is promising to explore the pharmacodynamic mechanism of Chinese medicine compound preparation and its main active ingredients on RA angiogenesis. This article aimed to investigate traditional Chinese medicine compound formulations with "warming the meridians and dispelling cold" and "dispelling wind and dampness" effects, along with their primary active components, to provide a theoretical basis for their therapeutic application in RA through anti-inflammatory, anti-FLS proliferation, and anti-angiogenic pathways.

Key words: Arthritis, rheumatoid, Chinese traditional medicine, Drugs, Chinese herbal, Pharmacology

Lingfeng Ma, Xiaoshan Zhang, Ying Wei, Minjie Zhang, Chao Yu, Yaxi Wang. Study progress in pharmacodynamic mechanism of Chinese medicine on rheumatoid arthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(06): 708-713.

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