Advances in role and mechanism of Piezo1 in mediating post-traumatic osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2023.04.010

Abstract

Abstract:

Post-traumatic osteoarthritis is a degenerative joint disease following trauma, mainly characterized by the abnormal regulation of chondrocytes cartilage degeneration. The pathogenesis of post-traumatic osteoarthritis is the result of biomechanics and cell biology, but the key mechanism is unclear.Studies have shown that mechanical sensitive protein Piezo1, as a mechanical receptor, converts mechanical - electrochemical signals by sensing cell membrane mechanical stimulation, which is closely related to the pathological occurrence and progression of post-traumatic osteoarthritis.This review showed the related studies on the mechanism of Piezo1-mediated post-traumatic osteoarthritis and discusses the possibility of Piezo1 as an intervention target for post-traumatic osteoarthritis in the future.

Key words: Osteoarthritis, Chondrocytes, Ion channels, Stress, mechanical

Fan Luo, Zhitao Rao. Advances in role and mechanism of Piezo1 in mediating post-traumatic osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(04): 528-533.

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