Research progress of exosomal non-coding RNA in pathogenesis of osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2023.04.009

Abstract

Abstract:

Exosomes are extra-cellular vesicles with a diameter of 50-150 nm secreted by a variety of cells. They play an important role in paracrine, immune regulation and inter-cellular communication under physiological and pathological conditions. Studies have shown that non-coding RNAs (ncRNA) such as micro RNAs (miRNA) and long non-coding RNAs (ncRNA) in exosomes are involved in the regulation of osteoarthritis (OA) pathogenesis. The mechanisms are as follows: miRNA can bind messenger RNA (mRNA) and affect its transcription and the following translation, while lncRNA can competitively bind miRNA and inhibit the regulation of miRNA on mRNA transcription. In this way, ncRNA can regulate the expression of downstream target genes, affecting cell apoptosis and proliferation, regulating chondrocyte extracellular matrix metabolism, and regulating inflammation responses and therefore regulating the pathogenesis of osteoarthritis. The research of exosomal ncRNA will help to further understand the pathogenesis of OA, delay the progression of OA, promote the repair of cartilage damage and promote the development of targeted therapy.

Key words: Exosomes, RNA, untranslated, MicroRNAs, RNA, long noncoding, Osteoarthritis

Jinglong He, Wei Sun, Minghong Gao, Wei Xie, Luogong Jiang, Qifei He, Jiaji Yue. Research progress of exosomal non-coding RNA in pathogenesis of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(04): 520-527.

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References 53

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ncRNA种类	促进软骨细胞增殖或抑制软骨细胞凋亡	抑制软骨细胞增殖或促进软骨细胞凋亡
miRNA	miR-210^[20]，miR-8485^[21]，miR-320c^[22]，miR-291a-3p^[28]，miR-196a-5p^[28]，miR-23a-3p^[28]，miR-24-3p^[28]	miR-34a^[15,16]，miR-108a^[15]，miR-384-5p^[17]，miR-181a^[18]，miR-146b^[19]，miR-206^[23,27]，miR-27a-3p^[26]
lncRNA	lncRNA KLF3-AS1^[23]，lncRNA ZFAS1^[24]，lncRNA PACER^[25]，lncRNAFOXD2-AS1^[26,27]	lncRNA Nespas^[28]，lncRNA PVT1^[29,30]

ncRNA种类	促进软骨细胞增殖或抑制软骨细胞凋亡	抑制软骨细胞增殖或促进软骨细胞凋亡
miRNA	miR-210^[20]，miR-8485^[21]，miR-320c^[22]，miR-291a-3p^[28]，miR-196a-5p^[28]，miR-23a-3p^[28]，miR-24-3p^[28]	miR-34a^[15,16]，miR-108a^[15]，miR-384-5p^[17]，miR-181a^[18]，miR-146b^[19]，miR-206^[23,27]，miR-27a-3p^[26]
lncRNA	lncRNA KLF3-AS1^[23]，lncRNA ZFAS1^[24]，lncRNA PACER^[25]，lncRNAFOXD2-AS1^[26,27]	lncRNA Nespas^[28]，lncRNA PVT1^[29,30]

ncRNA种类	促进ECM合成或抑制ECM降解	抑制ECM合成或促进ECM降解
miRNA	miR-221^[33]，miR-145^[34]，miR-4784^[35]，miR-29a^[36]，miR-140^[37]，miR-27b^[38]	miR-483-5p^[31]，miR-16-5p^[32]
lncRNA	lncRNA KLF3-AS1^[39]	lncRNA CIR^[38]
circRNA	circSERPINE2^[43,44]	circ_0136474^[41]，circ_CDR1as^[42]

ncRNA种类	促进ECM合成或抑制ECM降解	抑制ECM合成或促进ECM降解
miRNA	miR-221^[33]，miR-145^[34]，miR-4784^[35]，miR-29a^[36]，miR-140^[37]，miR-27b^[38]	miR-483-5p^[31]，miR-16-5p^[32]
lncRNA	lncRNA KLF3-AS1^[39]	lncRNA CIR^[38]
circRNA	circSERPINE2^[43,44]	circ_0136474^[41]，circ_CDR1as^[42]

ncRNA种类	抑制关节内炎症反应	加剧关节内炎症反应
miRNA	miR-149^[47]，miR-138^[49]，miR-216a-5p^[51]，miR-12496^[52]	miR-26a-5p^[45]
lncRNA	lncRNA GACAT3^[50]，lncRNA PACER^[25]	lncRNA DANCR^[51]，lncRNA HOTAIR^[52]，lncRNA LOC101928134^[53]

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