To analyze the influence of preoperative stress response on postoperative pain in patients undergoing joint replacement surgery, in order to provide guidance for later clinical treatment.

A total of 102 patients with joint replacement surgery who received treatment in our hospital from August 2019 to August 2020 were included in the prospective analysis according to the inclusion criteria and exclusion criteria. The serum oxidative stress index content of the patients before and six months after surgery was compared by t test. Visual analogue scale (VAS) was used to evaluate the pain situation after surgery. The correlation between stress and postoperative pain before and after joint replacement surgery was analyzed by Pearson correlation.

Compared with preoperation, the contents of malondialdehyde (MDA), myeloperoxidase (MPO) and advanced protein oxidation products (AOPPs) in serum of postoperative patients significantly decreased; serum antioxidant indicators, such as superoxide dismutase (SOD) and total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) levels were elevated (t=2.365, 3.929, 2.175, 2.419, 2.319, 2.263, all P<0.05). Compared with preoperative and postoperative serum inflammatory factors in patients with interleukin-2 (IL-2) and interleukin 6 (IL-6) and interleukin 8 (IL-8), tumor necrosis factor alpha (TNF α) and c-reactive protein (CRP) levels were significantly lower (t=4.137, 2.421, 4.763, 3.827, 2.274, all P<0.05). The VAS score on the third day before surgery was (4.1±1.1). Pearson correlation analysis showed that preoperative serum MDA, MPO and AOPPs were positively correlated with postoperative pain(r=0.421, 0.371, 0.486, all P<0.05). SOD, T-AOC and GSH-Px levels were negatively correlated with postoperative pain (r=-0.135, -0.176, -0.332, all P<0.05). Preoperative serum levels of IL-2, IL-6, IL-8, TNF-α and CRP were positively correlated with postoperative pain (r=0.426, 0.411, 0.548, 0.223, 0.302, all P<0.05).

The preoperative stress and inflammation are closely related to the postoperative pain of patients undergoing joint replacement surgery. The more severe the preoperative stress and inflammation, the more obvious the postoperative pain.