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Chinese Journal of Joint Surgery(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (04): 437-442. doi: 10.3877/cma.j.issn.1674-134X.2019.04.009

Special Issue:

• Meta Analysis • Previous Articles     Next Articles

Meta analysis on correlation between metabolic syndrome and osteoarthritis

Tengfeng Zhuang1, Xiaofei Zheng1, Ning Liu1, Huige Hou1, Songwei Huan1, Shengchun Wang1, Huajun Wang1,(), Zhengang Zha1   

  1. 1. Department of bone and joint surgery, the First Affilated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2018-05-19 Online:2019-08-01 Published:2019-08-01
  • Contact: Huajun Wang
  • About author:
    Corresponding author: Wang Huajun, Email:

Abstract:

Objective

To systematically assess the relationship between metabolic syndrome and osteoarthritis.

Methods

Databases including PubMed, Excerpta Medica Database(EMbase), China Biology Medicine disc (CBM), China Science and Technology Journal Database(VIP), the Cochrane Library(Issue 5, 2018), China National Knowledge Infrastructure (CNKI) and WanFang Data were searched for the published studies including the investigation of the correlation between metabolic syndrome and osteoarthritis from inception to May 2018. The observational trials about correlation between metabolic syndrome and osteoarthritis were included, and repeat published literatures were excluded. Two authors specifically assessed literature according to the inclusion and exclusion criteria, acquired data and evaluated the risk of bias of involved studies. Meta-analysis was performed using RevMan 5.3 software.

Results

A total of nine studies including 25 096 patients were involved. The results of meta-analysis showed that pooled crude risk of occurrence of osteoarthritis in metabolic syndrome population was 2.23 times of the non-metabolic-syndrome population[OR=2.23, 95%CI(1.48, 3.36), P=0.0001], and pooled adjusted risk of occurrence of osteoarthritis in metabolic syndrome population was still greater than non-metabolic-syndrome population[OR=1.05, 95%CI(1.03, 1.07), P<0.01].

Conclusion

Metabolic syndrome is associated with osteoarthritis, which increases risk of osteoarthritis.

Key words: Metabolic syndrome, Osteoarthritis, Meta-analysis

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