Effect of Vitamin K2 combined with Vitamin D3 on young patients of early osteoarthritis of knee

doi:10.3877/cma.j.issn.1674-134X.2018.02.010

Abstract

Abstract:

Objective

To explore the clinical effect of vitamin K2 combined with vitamin D3 on the young patients of early osteoarthritis of the knee.

Methods

From January 2016 to June 2017, 387 cases of young patient with pain of the knee were chosen in our hospital. And then according to the inclusive criteria, 132 cases were asked to take both vitamin K2(VK) and vitamin D3(VD) for 6 months. 25-OH-VD, procollagenⅠN-terminal peptide (P1NP) of the serum, VAS score and the muscle strength of four biceps femoris were the research objects before and after treatment.

Results

After six months, 25-OH-VD, P1NP of the serum and the muscle strength of four biceps femoris were increased with statistical significance before treatment (P<0.05), while the VAS scores were decreased with statistical significance before treatment (P<0.05). And 33 cases were suggested with loss of cartilages and bone edema in the tibia and femur under X-ray and MRI before treatment.

Conclusion

VK2 combined with VD3 could release the pain and improve the activity of the young patients of early osteoarthritis of the knee properly through bone metabolism and osteogenesis. The young patients of early osteoarthritis of the knee should get enough intervention as soon as possible.

Key words: Vitamin K, Vitamin D, Osteoarthritis, knee, Osteoporosis

Long Ling, Hailan Hu, Yanming Cao, Cong Zheng, Mingming Li, Xiao Wei, Kangyan Liu. Effect of Vitamin K2 combined with Vitamin D3 on young patients of early osteoarthritis of knee[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(02): 197-202.

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References 29

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?	血清25-OH-VD(ng/ml)	血清P1NP(ng/ml)	VAS评分	股四头肌最大肌力(N)	股四头肌平均肌力(N)
治疗前	22.0±4.9	35.4±15.8	6.2±1.5	12.6±4.7	11.70±4.5
治疗后	30.3±5.0	51.6±16.1	2.6±0.7	17.6±4.9	16.20±3.9
t值	2.664	3.265	3.762	3.005	2.564
P值	<0.01	<0.01	<0.01	<0.01	<0.01

?	血清25-OH-VD(ng/ml)	血清P1NP(ng/ml)	VAS评分	股四头肌最大肌力(N)	股四头肌平均肌力(N)
治疗前	22.0±4.9	35.4±15.8	6.2±1.5	12.6±4.7	11.70±4.5
治疗后	30.3±5.0	51.6±16.1	2.6±0.7	17.6±4.9	16.20±3.9
t值	2.664	3.265	3.762	3.005	2.564
P值	<0.01	<0.01	<0.01	<0.01	<0.01

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