Abstract:
Objective To investigate the clinical effect of platelet-rich plasma (PRP) combined with arthroscopic meniscus arthroplasty in the treatment of meniscus injury.
Methods A retrospective analysis was made on 100 patients with meniscus injury from November 2019 to November 2021 in Weihai the 970th Hospital of PLA. According to the treatment methods, they were divided into PRP group and control group, with 50 cases in each group. The control group was treated with arthroscopic meniscus plasty, and the PRP group was treated with platelet-rich plasma (PRP) on the basis of the control group. Chi-square test was used to evaluate the clinical efficacy of the two groups; independent sample t test was used to evaluate knee joint mobility, knee joint function, pain, quality of life, prognosis and serum inflammatory factors.
Results The total effective rate of the PRP group was 96%, which was higher than that of the control group (84%, χ2=4.000, P<0.05). Before treatment, there was no significant difference in knee joint activity, Lysholm score or quality of life questionnaire (QOL)-74 score between the two groups(all P>0.05); after treatment, the scores of knee range of motion, Lysholm and QOL -74 were increased in both groups, and those in the PRP group were higher than those in the control group(t=3.478, 5.228, 3.525, 10.534, all P<0.05). After treatment, the visual analogue scale (VAS) was decreased in both groups, and the VAS in the PRP group was lower than that in the control group(t=10.534, P<0.05). The assistant walking of patients in the PRP group was better than that in the control group(t=9.052, P<0.05). There was no significant difference in the level of serum inflammatory factors (C-reactive protein, interleukin-6, tumor necrosis factor-α) between the two groups before treatment(all P>0.05). After 72 h of treatment, the inflammatory factors in the two groups increased, but the PRP group were lower than the control group (t=30.423, 16.718, 12.110, all P<0.001).
Conclusion PRP combined with arthroscopic meniscus plasty has a good clinical effect on meniscus injury, which can effectively improve knee joint function and prognosis, relieve knee joint pain, improve quality of life and reduce knee joint inflammation.
Key words:
Platelet-rich plasma,
Knee joint,
Arthroscopy,
Tibial meniscus injuries,
Quality of life
Chuanlong Xia, Jian Chi, Qiang Cong, Jie Lian, Jun Cui, Yanling Chen. Clinical effects of platelet-rich plasma combined with arthroscopy on meniscus injury[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(06): 877-881.