Research progress in application of exosomes in diagnosis and treatment of osteoporosis

doi:10.3877/cma.j.issn.1674-134X.2023.05.011

Abstract

Abstract:

With the continuous upgrading of global aging process, the number of osteoporosis patients is also increasing year by year. At present, the treatment of osteoporosis and related orthopedic diseases is complex and varied, but there is a lack of ideal early or conservative intervention. Exosomes, as the key medium of signal communication between cells, carry proteins, nucleic acids, lipids and other substances that can mediate tissue metabolism. In recent years, relevant studies have demonstrated that exosomes play a very important role in the formation, metabolism and pathological changes of bone and cartilage. Exosomes can not only be used as a substitute for traditional orthopedic diseases, but also as an important marker for the identification of orthopedic diseases due to their advantages of small size, rich source and low immunogenicity. This paper reviewed the research progress of exosomes from various cell sources in the diagnosis and treatment of osteoporosis and related orthopedic diseases, providing theoretical basis for further research and clinical application of exosomes in related orthopedic diseases, so as to open up a new road in the field of clinical prevention and treatment.

Key words: Exosomes, Osteoporosis, Osteoarthritis, Osteonecrosis

Yan Wang, Jianxiong Ma, Shuang Lang, Benchao Dong, Aixian Tian, Yan Li, Lei Sun, Hongzhen Jin, Bin Lu, Ying Wang, Haohao Bai, Xinlong Ma. Research progress in application of exosomes in diagnosis and treatment of osteoporosis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 673-678.

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