Research progress of exosomes derived from mesenchymal stem cells in treatment of osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2022.02.009

Abstract

Abstract:

Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage. Many studies have shown that mesenchymal stem cells can promote the repair of cartilage tissue of OA and improve the joint environment. Some co-cultivation experiments of mesenchymal stem cells and chondrocytes indicate that mesenchymal stem cells may act by secreting some cytokines, and exosomes are an important component of these factors.In vitro experiments confirmed that both exosomes and mesenchymal stem cells derived from mesenchymal stem cells can promote chondrocyte proliferation, maintain chondrocyte phenotype, inhibit chondrocyte apoptosis, promote cartilage extracellular matrix synthesis, and promote chondrocyte migration. In vivo experiments have also shown that exosomes derived from mesenchymal stem cells in OA can repair cartilage, promote cartilage matrix synthesis, and inhibit inflammatory cell infiltration. Compared with mesenchymal stem cell therapy, exosomal therapy alone has the advantages of safety and low cost. This provides a new strategy for the treatment of OA. However, the mechanism of MSCs-EXs in the treatment of osteoarthritis is not clear. This article reviewed the research progress of MSCs-EXs in the treatment of OA.

Key words: Mesenchymal stem cells, Exosomes, Osteoarthritis, Chondrocytes

Zicai Fu, Yong Huang, Fei Chen, Shuyu Liu, Weimin Zhu. Research progress of exosomes derived from mesenchymal stem cells in treatment of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2022, 16(02): 196-201.

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References 36

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作者	来源细胞	miRNA	靶基因	作用
Chen^[27]^, 2020	BM-MSCs	miR-136-5p	ELF3	促进软骨细胞迁移能力，增加Col Ⅱ、ACAN、SOX9的表达，减少MMP13表达
He^[28]^, 2020	BM-MSCs	miR-210	NF-κB	抗炎，促进软骨细胞增殖，抑制软骨细胞凋亡
Sun^[29]^, 2018	BM-MSCs	miR-320c	/	促进BM-MSCs成软骨分化，促进软骨细胞增殖、迁移及SOX9表达。减低MMP13表达
Dong^[30]^, 2021	BM-MSCs	miR-127-3p	CDH11	抗软骨细胞凋亡，促进Col II表达，减少MMP13表达
Jin^[31]^, 2020	BM-MSCs	miR-9-5p	Syndecan-1	减少软骨缺损，降低IL-1、IL-6、TNF-α、NO、COX2、CRP表达
Wu^[32]^, 2019	髌下脂肪垫的间充质干细胞	miR-100-5p	mTOR	促进软骨细胞Col Ⅱ表达，抑制MMP13、ADAMTS5的表达

作者	来源细胞	miRNA	靶基因	作用
Chen^[27]^, 2020	BM-MSCs	miR-136-5p	ELF3	促进软骨细胞迁移能力，增加Col Ⅱ、ACAN、SOX9的表达，减少MMP13表达
He^[28]^, 2020	BM-MSCs	miR-210	NF-κB	抗炎，促进软骨细胞增殖，抑制软骨细胞凋亡
Sun^[29]^, 2018	BM-MSCs	miR-320c	/	促进BM-MSCs成软骨分化，促进软骨细胞增殖、迁移及SOX9表达。减低MMP13表达
Dong^[30]^, 2021	BM-MSCs	miR-127-3p	CDH11	抗软骨细胞凋亡，促进Col II表达，减少MMP13表达
Jin^[31]^, 2020	BM-MSCs	miR-9-5p	Syndecan-1	减少软骨缺损，降低IL-1、IL-6、TNF-α、NO、COX2、CRP表达
Wu^[32]^, 2019	髌下脂肪垫的间充质干细胞	miR-100-5p	mTOR	促进软骨细胞Col Ⅱ表达，抑制MMP13、ADAMTS5的表达

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