Research progress in treatment of osteoarthritis targeting subchondral bone sclerosis

doi:10.3877/cma.j.issn.1674-134X.2021.02.012

Abstract

Abstract:

Osteoarthritis (OA) is a joint degenerative disease characterized by articular cartilage degeneration and subchondral osteosclerosis. The pathological features were articular cartilage degeneration and destruction, subchondral osteosclerosis or cystic change, articular marginal hyperosteogeny, synovial lesions, articular capsule contracture, ligament relaxation or contracture, muscle atrophy and weakness, etc. In recent years, studies have found that subchondral osteosclerosis is a cause of OA, and subchondral osteosclerosis is superior to and accelerates the degeneration of cartilage, thus accelerating the development of OA. It is of great significance to inhibit or delay subchondral osteosclerosis in the treatment of OA. This article reviewed the research progress of OA treatment with subchondral bone sclerosis as the target, and provides help for follow-up basic research and clinical work.

Key words: Cartilage, Research, Osteoarthritis, Therapeutics

Mingyi Yang, Yani Su, Yao Ma, Ke Xu, Changjun He, Wangli Huang, Qingda Li, Xiaoyu Ren, Bo Hao, Peng Xu. Research progress in treatment of osteoarthritis targeting subchondral bone sclerosis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2021, 15(02): 209-213.

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