Role of microRNA-140 in pathogenesis of osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2020.01.012

Abstract

Abstract:

Osteoarthritis is a degenerative diseases mainly in articular cartilage, but its pathogenesis has not been elucidated yet. MicroRNA-140(miR-140) is a specific and high expression microRNA in cartilage, which plays an essential role in chondrogenesis, proliferation, mature, differentiation, aging as well as apoptosis. However, due to its complex role, the molecular mechanism of miR-140 in the pathogenesis of osteoarthritis is unclear yet. Thus, this article reviewed recent literatures in order to discuss the role of miR-140 in chondorgenesis, cartilage homeostasis and degeneration as well as early diagnosis of osteoarthritis.

Key words: MicroRNAs, Osteoarthritis, Chondrocyte

Canfeng Li, Tian You, Bin Shen. Role of microRNA-140 in pathogenesis of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2020, 14(01): 68-72.

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