Application of molecular markers in diagnosis of periprosthetic joint infection

doi:10.3877/cma.j.issn.1674-134X.2019.04.012

Abstract

Abstract:

Periprosthetic infection (PJI) is a disastrous complication after artificial joint replacement. Early diagnosis is crucial to the prognosis of patients with periprosthetic infection. Currently, there are many existing diagnostic methods, but there is no uniform " gold standard" . In recent years, molecular markers are expected to be a new method to diagnose PJI. This paper reviewed the progress of molecular diagnosis of PJI by referring to the latest literature.

Key words: Infection, Joint prosthesis, Diagnosis, Biomarkers

Yihong Xu, Shuo Li, Weidong Xu. Application of molecular markers in diagnosis of periprosthetic joint infection[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(04): 455-460.

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URL: https://zhgjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-134X.2019.04.012

https://zhgjwkzz.cma-cmc.com.cn/EN/Y2019/V13/I04/455

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References 49

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?	分子标记物	得分	诊断
血清	血清中升高的CRP或D-二聚体	2	?
血清	血清中升高的血沉	1	≥6分感染
滑液	关节液中升高的白细胞计数或白细胞酯酶	3	2～5分可能感染
滑液	关节液中α-防御素阳性	3	<2分排除感染
?	关节液中多形核百分比升高	2	?
?	关节液中CRP升高	1	?

?	分子标记物	得分	诊断
血清	血清中升高的CRP或D-二聚体	2	?
血清	血清中升高的血沉	1	≥6分感染
滑液	关节液中升高的白细胞计数或白细胞酯酶	3	2～5分可能感染
滑液	关节液中α-防御素阳性	3	<2分排除感染
?	关节液中多形核百分比升高	2	?
?	关节液中CRP升高	1	?

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