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Chinese Journal of Joint Surgery(Electronic Edition) ›› 2018, Vol. 12 ›› Issue (02): 245-250. doi: 10.3877/cma.j.issn.1674-134X.2018.02.017

Special Issue:

• Review • Previous Articles     Next Articles

Research advance of periostin protein and its role in osteoarthritis

Jiayao Ouyang1, Chun Zeng1, Chang Zhao1, Daozhang Cai1, Hang Fang1,()   

  1. 1. Department of Joint Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
  • Received:2016-09-13 Online:2018-04-01 Published:2018-04-01
  • Contact: Hang Fang
  • About author:
    Corresponding allthor: Fang Hang, Email:

Abstract:

Periostin is a 90 kDa matricellular protein, which plays an important role in many aspects of cell adhesion, fibrosis, response to mechanical strain, regulating bone metabolism and tendon remodeling. In recent years, many studies have discovered that periostin may be closely related to osteoarthritis, which would become a novel and latent site to diagnose and treat with osteoarthris earlier. This article paid attention to studies on periostin domestically and abroad, and discussed mainly about the structure and functions of periostin and its research progresses in osteoarthritis.

Key words: POSTN protein, human, Cell adhesion, Fibrosis, Stress, mechanical, Metabolism, Bone remodeling, Osteoarthritis

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