Abstract:

Necrosis of the femoral head is a common and difficult-to-treat hip disease in orthopedics，with the main clinical manifestations of claudication， limitation of hip flexion and extension activities， and hip pain. If left untreated once the femoral head collapses or secondary osteoarthritis occurs， total hip replacement is eventually required. Currently， the clinical treatment of femoral head necrosis is mainly based on Association Research Circulation Osseous （ARCO） staging to choose different treatment modalities. Early-stage patients are usually treated with "hip preservation"， and the commonly used surgical methods include medullary decompression， autologous bone grafting， stem cell therapy， etc.， while total hip arthroplasty is often used for advanced patients. However， prevention of collapse has always been the key point in the treatment of femoral head necrosis. In recent years， platelet-rich plasma （PRP） has been effective in promoting cartilage repair and vascular regeneration of the femoral head. Therefore， this paper summarized the mechanism of PRP in the treatment of femoral head necrosis and its clinical application， with a view to providing reference and direction for subsequent research.

Key words: Femoral head necrosis, Platelet rich plasma, Intercellular signaling peptides and proteins, Review