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中华关节外科杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 245 -250. doi: 10.3877/cma.j.issn.1674-134X.2018.02.017

所属专题: 文献

综述

骨膜蛋白及其在骨关节炎方面的研究进展
欧阳家耀1, 曾春1, 赵畅1, 蔡道章1, 方航1,()   
  1. 1. 510630 广州,南方医科大学第三附属医院关节外科
  • 收稿日期:2016-09-13 出版日期:2018-04-01
  • 通信作者: 方航
  • 基金资助:
    高等学校博士学科点专项科研基金资助项目(20124433110021)

Research advance of periostin protein and its role in osteoarthritis

Jiayao Ouyang1, Chun Zeng1, Chang Zhao1, Daozhang Cai1, Hang Fang1,()   

  1. 1. Department of Joint Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
  • Received:2016-09-13 Published:2018-04-01
  • Corresponding author: Hang Fang
  • About author:
    Corresponding allthor: Fang Hang, Email:
引用本文:

欧阳家耀, 曾春, 赵畅, 蔡道章, 方航. 骨膜蛋白及其在骨关节炎方面的研究进展[J]. 中华关节外科杂志(电子版), 2018, 12(02): 245-250.

Jiayao Ouyang, Chun Zeng, Chang Zhao, Daozhang Cai, Hang Fang. Research advance of periostin protein and its role in osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(02): 245-250.

骨膜蛋白是一个分子量约为90 kDa的细胞外基质蛋白,在参与细胞连接、纤维化、感应机械应力和调控骨代谢与肌腱重塑等方面起着重要作用。近年来研究发现,骨膜蛋白与骨关节炎(OA)的发生和发展可能密切相关,有望成为早期诊断和早期治疗OA的新的潜在靶点。本文将结合国内外对骨膜蛋白的最新研究成果,重点讨论骨膜蛋白的结构、功能以及在OA方面的研究进展。

Periostin is a 90 kDa matricellular protein, which plays an important role in many aspects of cell adhesion, fibrosis, response to mechanical strain, regulating bone metabolism and tendon remodeling. In recent years, many studies have discovered that periostin may be closely related to osteoarthritis, which would become a novel and latent site to diagnose and treat with osteoarthris earlier. This article paid attention to studies on periostin domestically and abroad, and discussed mainly about the structure and functions of periostin and its research progresses in osteoarthritis.

[1]
Tang X, Wang SF, Zhan SY, et al. The prevalence of symptomatic knee osteoarthritis in China results from the China health and retirement longitudinal study[J]. Arthritis Rheumatol, 2016, 68(3):648-653.
[2]
Zhang R, Fang H, Chen Y, et al. Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray[J]. PLoS One, 2012, 7(2):e32356.
[3]
Takeshita S, Kikuno R, Tezuka K, et al. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I[J]. Biochem J, 1993, 294(Pt 1):271-278.
[4]
Horiuchi K, Amizuka N, Takeshita S, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta[J]. J Bone Miner Res, 1999, 14(7):1239-1249.
[5]
Blanchard C, Mingler MK, Mcbride M, et al. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses[J]. Mucosal Immunol, 2008, 1(4):289-296.
[6]
Bentley JK, Chen Q, Hong JY, et al. Periostin is required for maximal airways inflammation and hyperresponsiveness in mice[J]. J Allergy Clin Immunol, 2014, 134(6):1433-1442.
[7]
Kudo A. Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell[J]. Cell Mol Life Sci, 2011, 68(19):3201-3207.
[8]
Kudo Y, Siriwardena BS, Hatano H, et al. Periostin: novel diagnostic and therapeutic target for cancer[J]. Histol Histopathol, 2007, 22(10):1167-1174.
[9]
Baril P, Gangeswaran R, Mahon PC, et al. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway[J]. Oncogene, 2007, 26(14):2082-2094.
[10]
Shao R, Bao S, Bai X, et al. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression[J]. Mol Cell Biol, 2004, 24(9):3992-4003.
[11]
Morra L, Moch H. Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update[J]. Virchows Arch, 2011, 459(5):465-475.
[12]
Sasaki H, Yu CY, Dai M, et al. Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer[J]. Breast Cancer Res Treat, 2003, 77(3):245-252.
[13]
Ruan K, Bao S, Ouyang G. The multifaceted role of periostin in tumorigenesis[J]. Cell Mol Life Sci, 2009, 66(14):2219-2230.
[14]
Bao S, Ouyang G, Bai X, et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway[J]. Cancer Cell, 2004, 5(4):329-339.
[15]
Blumer MJ, Schwarzer C, Pérez MT, et al. Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre[J]. J Anat, 2006, 208(6):695-707.
[16]
Oka T, Xu J, Kaiser RA, et al. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling[J]. Circ Res, 2007, 101(3):313-321.
[17]
Hong L, Shejiao D, Fenrong C, et al. Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1[J]. J Cell Mol Med, 2015, 19(10):2462-2468.
[18]
Wallace DP, White C, Savinkova L, et al. Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease[J]. Kidney Int, 2014, 85(4):845-854.
[19]
Oku E, Kanaji T, Takata Y, et al. Periostin and bone marrow fibrosis[J]. Int J Hematol, 2008, 88(1):57-63.
[20]
Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain[M]. Calcif Tissue Int,1995, 57(5):344-358
[21]
Rios HF, Ma D, Xie Y, et al. Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice[J]. J Periodontol, 2008, 79(8):1480-1490.
[22]
Manokawinchoke J, Limjeerajarus N, Limjeerajarus C, et al. Mechanical force-induced TGFB1 increases expression of SOST/POSTN by hPDL cells[J]. J Dent Res, 2015, 94(7):983-989.
[23]
Padial-Molina M, Volk SL, Taut AD, et al. Periostin is Down-regulated during Periodontal Inflammation[J]. J Dent Res, 2012, 91(11):1078-1084.
[24]
Gruber HE, Norris RA, Kern MJ, et al. Periostin is expressed by cells of the human and sand rat intervertebral discs[J]. Biotech Histochem, 2011, 86(3):199-206.
[25]
Tsai TT, Lai PL, Liao JC, et al. Increased periostin gene expression in degenerative intervertebral disc cells[J]. Spine J, 2013, 13(3):289-298.
[26]
Rosselli-Murai LK, Almeida LO, Zagni C, et al. Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway[J/OL]. PLoS One, 2013, 8(12):e83580.
[27]
Bonnet N, Conway SJ, Ferrari SL. Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin[J]. Proc Natl Acad Sci U S A, 2012, 109(37):15048-15053.
[28]
Gerbaix M, Vico L, Ferrari SL, et al. Periostin expression contributes to cortical bone loss during unloading[J]. Bone, 2015, 71(71):94-100.
[29]
Oshima A, Tanabe H, Yan T, et al. A novel mechanism for the regulation of osteoblast differentiation: transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, twist[J]. J Cell Biochem, 2002, 86(4):792-804.
[30]
Litvin J, Selim AH, Montgomery MO, et al. Expression and function of periostin-isoforms in bone[J]. J Cell Biochem, 2004, 92(5):1044-1061.
[31]
Cobo T, Viloria CG, Solares L, et al. Role of periostin in adhesion and migration of bone remodeling cells[J/OL]. PLoS One, 2016, 11(1):e0147837.
[32]
Fortunati D, Reppe S, Fjeldheim AK, et al. Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone[J]. Matrix Biol, 2010, 29(7):594-601.
[33]
Noack S, Seiffart V, Willbold E, et al. Periostin secreted by mesenchymal stem cells supports tendon formation in an ectopic mouse model[J]. Stem Cells Dev, 2014, 23(16):1844-1857.
[34]
Chen KS, Tatarczuch L, Mirams M, et al. Periostin expression distinguishes between light and dark hypertrophic chondrocytes[J]. Int J Biochem Cell Biol, 2010, 42(6):880-889.
[35]
Chou CH, Wu CC, Song IW, et al. Genome-wide expression profiles of subchondral bone in osteoarthritis[J/OL]. Arthritis Res Ther, 2013, 15(6):R190.
[36]
Loeser RF, Olex AL, Mcnulty MA, et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice[J]. Arthritis Rheum, 2012, 64(3):705-717.
[37]
Lourido L, Calamia V, Mateos J, et al. Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis[J]. J Proteome Res, 2014, 13(12):6096-6106.
[38]
Rousseau JC, Sornay-Rendu E, Bertholon C, et al. Serum periostin is associated with prevalent knee osteoarthritis and disease incidence/progression in women: the OFELY study[J]. Osteoarthritis Cartilage, 2015, 23(10):1736-1742.
[39]
Honsawek S, Wilairatana V, Udomsinprasert W, et al. Association of plasma and synovial fluid periostin with radiographic knee osteoarthritis: cross-sectional study[M]. Joint Bone Spine, 2015, 82(5): 352-355.
[40]
Chijimatsu R, Kunugiza Y, Taniyama Y, et al. Expression and pathological effects of periostin in human osteoarthritis cartilage[J/OL]. BMC Musculoskelet Disord, 2015, 8(21)16:215. DOI 10.1186/s12891-015-0682-3
[41]
Attur M, Yang Q, Shimada K, et al. Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13[J]. FASEB J, 2015, 29(10):4107-4121.
[42]
Tajika Y, Moue T, Ishikawa S, et al. Influence of periostin on synoviocytes in knee osteoarthritis[J]. In Vivo, 2017, 31(1):69-77.
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